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Phospho-HDAC7A (Ser486) Rabbit Polyclonal Antibody#abs140207

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Description

Catalog-specification	Delivery time	USD price
abs140207-100ug	1-2 Weeks	301.0
abs140207-50ug	1-2 Weeks	201.0

Overview
catalog	abs140207
Other names	Here's an alternative way to rephrase the original content: The target of our discussion is a human protein with the aliases DKFZP586J0917, FLJ99588, HD 7a, HD7, HD7a, Hdac7, HDAC 7, HDAC 7A, HDAC7A, Histone deacetylase 7, Histone deacetylase 7A, OTTHUMP00000202813, and OTTHUMP00000202814. This protein is commonly known as HDAC7 and is involved in the regulation of gene expression by removing acetyl groups from histone proteins. HDAC7 plays a crucial role in multiple biological processes, including cell differentiation, cell cycle progression, and apoptosis. Its dysregulation has been linked to various diseases, including cancer and neurodegenerative disorders.
Source	Rabbit
Specificity	The antibody HDAC7A (Phospho-Ser486) specifically detects the presence of phosphorylated HDAC7A at Ser486, and it is designed to recognize the endogenous levels of this protein. To clarify, this antibody does not detect HDAC7A that is not phosphorylated at Ser486.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Pig;Dog;Horse;Bovine
Antigen	HDAC7A
Application	，WB（Western Blot）1:1000-3000，IF/ICC（/）1:100-1:500，ELISA（）1:20000-1:40000。，。，。
Immunogen	Let's discuss a peptide that has been synthesized using human HDAC7A (Phospho-Ser486) as the source. This synthesized peptide holds a high resemblance to the original content and is formed by rearranging the information provided.
MW	105kDa
Properties
Concentration	1mg/ml
purification	The purified rabbit serum was used to obtain the antibody through affinity purification techniques. This involved subjecting the serum to sequential chromatography on both phospho- and non-phospho-peptide affinity columns. As a result, the purified antibody is highly specific to the target antigen.
Clonality	Polyclonal Antibody
Stability & Storage	One year of storage is recommended at -20 °C. To maintain the quality of the product, it is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is as follows: It should be stored at a temperature of -20 °C. The IgG should be solubilized in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the IgG is stable for a period of 12 months from the date of receipt.
Target
Background	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
Posttranslational modification	May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.
Celluar localization	Cytosol;Nucleus;
UniPort	Q8WUI4