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Rabbit Anti-SLC4A8/10 Polyclonal Antibody#abs134834

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Description

Catalog-specification	Delivery time	USD price
abs134834-100ug	1-2 Weeks	301.0
abs134834-50ug	1-2 Weeks	201.0

Overview
catalog	abs134834
Other names	SLC4A10, also known as sodium-driven chloride bicarbonate exchanger or NBC, is a member of the solute carrier family 4. It is an electroneutral Na(+)-driven Cl-HCO3 exchanger that plays an important role in regulating ion balance in various tissues. Its function involves exchanging sodium ions for bicarbonate and chloride ions. Another related gene in this family is SLC4A8, which codes for the electroneutral sodium bicarbonate exchanger 1 or k-NBC3. This gene, also known as NBCn2 or NDCBE1, is involved in the transport of sodium and bicarbonate ions. Its function helps maintain the pH balance and electrolyte homeostasis in the body. Both SLC4A10 and SLC4A8 are essential for the proper functioning of various physiological processes. Their roles as sodium bicarbonate transporters make them crucial in maintaining acid-base balance and fluid secretion in different tissues and organs. In summary, SLC4A10 and SLC4A8 belong to the solute carrier family 4 and play key roles as sodium bicarbonate transporters. Their functions are essential for maintaining ion balance and pH homeostasis in the body.
Source	Rabbit
Specificity	The SLC4A8/10 Antibody is designed to detect the total levels of endogenous SLC4A8/10 protein present in a sample. The antibody ensures that it specifically recognizes and binds to the target protein. It is essential to use a reliable and verified antibody in experiments to obtain accurate results. With this antibody, researchers can investigate the expression, localization, and function of SLC4A8/10 protein in various biological systems.
Species Reactivity	Human;Mouse;Rat
Antigen	SLC4A8/10
Application	The recommended dilution for Western blotting is 1:500 to 1:1000. For immunofluorescence microscopy or immunocytochemistry, the suggested dilution range is 1:100 to 1:500. When it comes to ELISA using peptide as the antigen, the optimal dilution range is between 1:20000 and 1:40000. These dilution ranges provide a guideline for the appropriate concentration of antibodies or reagents to be used in these experimental techniques. It is important to follow these recommendations to ensure accurate and reliable results.
Immunogen	A synthesized peptide.
MW	140 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. Please generate a substantially varied content by reorganizing the given information.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3- exchange with a Na+:HCO3- stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3- from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3- into the cells. Also mediates lithium-dependent HCO3- cotransport. May be regulated by osmolarity.
Tissue specificity	Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.
Celluar localization	Plasma Membrane;
UniPort	Q2Y0W8/Q6U841