Rabbit Anti-EGR2 Polyclonal Antibody #abs130366

abs130366-50ug

1-2 Weeks

201

abs130366-100ug

1-2 Weeks

301

Description

Type 1 autosomal dominant Charcot-Marie-Tooth disease is linked to mutations in the early growth response protein 2 gene. This gene encodes a transcription factor that contains three consecutive C2H2-type zinc fingers. The presence of these zinc fingers is crucial for the protein's function.

Other names

EGR1 and EGR2 are transcription factors that play important roles in various cellular processes. EGR1, also known as early growth response protein 1, and EGR2, also known as early growth response protein 2 or Krox-20, are both zinc finger proteins that regulate gene expression.
EGR1 is involved in the regulation of cell growth, differentiation, and apoptosis. It acts as a transcriptional activator and can target a wide range of genes. On the other hand, EGR2 is primarily expressed in the nervous system and has a crucial role in myelination and neuronal development. It is highly expressed in Schwann cells and is necessary for the formation of myelinated nerves.
Interestingly, EGR2 can also be modified by E3 SUMO-protein ligase, which regulates its activity and subcellular localization. This post-translational modification process ensures the proper functioning of EGR2 in different cellular contexts.
Another member of the early growth response family is the Early growth response protein 1 (EGR1), also known as NGFI-A or TIS8. EGR1 is a transcription factor that is rapidly induced by various stimuli, including growth factors, stress, and neuronal activity. It plays a crucial role in the regulation of immediate early genes and can activate or repress gene expression depending on the context.
In addition to their role in normal physiological processes, alterations in EGR1 and EGR2 have been implicated in several diseases. For instance, mutations in EGR2 have been associated with Charcot-Marie-Tooth disease type 1D (CMT1D) and CMT4E, which are inherited peripheral neuropathies characterized by motor and sensory deficits.
Overall, EGR1 and EGR2 are key transcription factors that regulate gene expression and play important roles in various cellular processes, particularly in the nervous system. Understanding their functions and regulatory mechanisms can provide crucial insights into both normal development and disease pathogenesis.

Source

Rabbit

Specificity

EGR2 Antibody detects endogenous levels of EGR2

Species Reactivity

Rat;Human;Mouse

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human EGR2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To ensure proper storage, keep the item at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freezing and thawing cycles during this time period.

Storage buffer

This product is Rabbit IgG suspended in a solution of phosphate buffered saline at pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. The product is stable for a duration of 12 months starting from the date of its receipt.

Target

Background

HOXA4 promoter region contains two specific sites which are bound by a transcription factor that has a sequence-specific DNA-binding capability. The transcription factor plays a key role in regulating gene expression by binding to these DNA sites. Its ability to recognize and bind to these sites allows for precise control of HOXA4 expression, which is essential for proper development and maintenance of various tissues and organs. By interacting with the regulatory elements in the HOXA4 promoter region, the transcription factor ensures that the correct genes are expressed at the right time and in the correct cellular context.

Posttranslational modification

Proteasomal degradation occurs when a protein is ubiquitinated by WWP2, causing its subsequent breakdown.

Celluar localization

Nucleus;

UniPort

P11161