Rabbit Anti-TBX1 Polyclonal Antibody #abs130263

abs130263-50ug

1-2 Weeks

201

abs130263-100ug

1-2 Weeks

301

Description

A possible transcriptional regulator plays a crucial role in regulating developmental processes, particularly in the normal formation of the pharyngeal arch arteries. There are three isoforms of this human protein produced through alternative splicing, highlighting its significance in biological functions.

Other names

1. The T-box transcription factor TBX1, also known as T-box 1, plays a crucial role in various developmental processes.
2. One of the key functions of TBX1 is the regulation of brachyury, CAFS, CTHM, DGCR, DGS, DORV, and other genes involved in embryogenesis.
3. TBX1, also referred to as T-box protein 1 or TGA, is a highly specific transcription factor primarily expressed in the testis.
4. TBX1C, the C-terminal isoform of TBX1, is involved in the regulation of gene expression during testicular development.
5. The T-box transcription factor TBX1 is associated with genetic disorders such as VCFS (Velo-Cardio-Facial Syndrome) due to its importance in embryonic development.
6. The T box 1 transcription factor, along with its isoform TBX1C, plays a crucial role in the development of various organs and tissues in the body.
7. Mutations in the TBX1 gene can result in serious congenital malformations, including double outlet right ventricle (DORV).
8. The T-box transcription factor TBX1 acts as a master regulator during embryogenesis, controlling the expression of multiple target genes.
9. TBX1_HUMAN, the human variant of the TBX1 gene, has been extensively studied to understand its role in normal development and disease.
10. The testis-specific T-box protein, encoded by the tbx1 gene, is essential for proper testicular development and function.

Source

Rabbit

Specificity

Total TBX1 can be detected through the use of TBX1 antibodies, which are capable of identifying endogenous levels of the protein. To create similar content based on this information, it could be rephrased as follows: Endogenous levels of total TBX1 are detectable with the aid of specific TBX1 antibodies, which are designed to recognize the protein of interest.

Species Reactivity

Human

Application

Western blotting (WB) is typically performed at dilutions ranging from 1:500 to 1:3000, while immunofluorescence (IF) and immunocytochemistry (ICC) are commonly conducted at dilutions of 1:100 to 1:500. For ELISA assays using peptides, the recommended dilution range is typically 1:20000 to 1:40000. It is important to adhere to these dilution ranges to ensure accurate and reliable results in these experimental techniques.

Immunogen

A synthesized peptide derived from human TBX1

Properties

Concentration

1mg/ml

Purification

Affinity-chromatography

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze and thaw cycles as this can compromise its efficacy. Ensuring proper storage of the product will help to maintain its effectiveness and maximize its shelf life.

Storage buffer

This Rabbit IgG is suspended in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. It is also mixed with 50% glycerol to enhance its stability. To maintain its potency, this IgG should be stored at a freezing temperature of -20 °C. It has a shelf life of 12 months from the date of receipt.

Target

Background

A likely transcriptional regulator plays a crucial role in various developmental processes. Its presence is vital for the proper formation of the pharyngeal arch arteries during development. These findings suggest that this regulatory factor is essential for normal growth and development of numerous organs and tissues in the body.

Celluar localization

Nucleus;

UniPort

O43435