Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-MARK3 Polyclonal Antibody#abs133437

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Please refrain from asking questions or engaging in a conversation based on the generated text from ChapGPT. Instead, I will provide information...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs133437-50ug	1-2 Weeks	201.0
abs133437-100ug	1-2 Weeks	301.0

Overview
catalog	abs133437
Other names	Protein kinase STK10, also known as MAP microtubule affinity regulating kinase 3 or Mark3, is a serine/threonine protein kinase that is associated with Cdc25C and plays a crucial role in cell cycle regulation. It is also referred to as Cdc25C-associated protein kinase 1 or PAR1A. Another name for this kinase is C-TAK1, which stands for Cdc25C associated protein kinase 1. Additionally, it goes by the names ELKL motif kinase 2 or EMK-2. The alternative designation for this protein is ETK 1 or KP78. KIAA4230 is another name associated with this kinase. Ser/Thr protein kinase PAR-1 or serine threonine protein kinase p78 are other terms used for this protein, reflecting its classification among the PAR-1 family of serine/threonine kinases. Overall, this kinase is known by multiple names due to its various roles and associations within cellular processes.
Source	Rabbit
Specificity	The MARK3 Antibody can detect the complete amount of MARK3 that exists naturally within the organism. In order to create a highly similar content, the original text information should be rearranged and incorporated into new sentences.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;
Antigen	MARK3
Application	The recommended dilutions for Western Blotting (WB) range from 1:500 to 1:1000. For Immunohistochemistry (IHC), it is suggested to dilute the antibody from 1:50 to 1:200. When performing Immunofluorescence/Immunocytochemistry (IF/ICC), the antibody can be used at dilutions of 1:100 to 1:500. In the case of ELISA using a peptide antigen, the recommended dilution is 1:20000 to 1:40000. These dilution ranges ensure optimal results when using the antibody for different experimental techniques.
Immunogen	A synthesized peptide.
MW	85 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is advisable to avoid subjecting the product to frequent thawing and freezing cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).
Tissue specificity	Ubiquitous.
Posttranslational modification	Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.
Celluar localization	Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	P27448