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Rabbit Anti-P2RX7 Polyclonal Antibody#abs137612

Please note that the price mentioned above is just for your reference. In order to obtain detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent. Western blot analysis P2RX7 using Jurkat whole cell lysates This product is for research use only,...

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Description

Catalog-specification	Delivery time	USD price
abs137612-100ug	1-2 Weeks	301.0
abs137612-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is just for your reference. In order to obtain detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent.

Overview
catalog	abs137612
Other names	The ATP receptor known as P2rx7 or P2RX7_HUMAN is a purinergic receptor called P2X7. This receptor functions as a ligand-gated ion channel and is also referred to as the P2Z receptor. Its primary role is to bind to ATP and transmit signals within cells. The P2X7 receptor plays crucial roles in various physiological processes, including immune response, inflammation, and cell death. By rearranging the provided information, a content with a focus on the physiological and cellular functions of the P2X7 receptor can be generated.
Source	Rabbit
Specificity	The P2RX7 Antibody is capable of identifying the complete levels of indigenous P2RX7. The detected signals correspond to the overall expression of P2RX7 in the cells rather than any specific subtypes.
Species Reactivity	Human
Antigen	P2RX7
Application	The recommended dilution for WB is between 1:1000 and 1:3000, while for IHC, it should be between 1:50 and 1:200. As for ELISA using peptides, the suggested dilution is 1:20000-1:40000. These dilution ratios are crucial in ensuring reliable and accurate results in these assays. It's important to note that using lower or higher concentrations can lead to inaccurate results. Hence, researchers must follow the recommended dilution ratios for each assay.
Immunogen	A synthesized peptide derived from human P2RX7.
MW	69 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was accomplished through peptide affinity chromatography. Careful and precise techniques were utilized to ensure that the final product was highly purified with minimal contamination. The chromatography method involved the selective binding of peptides to the resin to isolate and extract the antiserum for further use. Through this process, a highly purified and effective antiserum was obtained.
Clonality	Polyclonal Antibody
Stability & Storage	-20°C。。，。
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the IgG in this manner for a period of 12 months from the date of receipt. It is essential to maintain these storage conditions to ensure the stability and efficacy of the Rabbit IgG.
Target
Background	Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Tissue specificity	Widely expressed with highest levels in brain and immune tissues.
Posttranslational modification	Phosphorylation results in its inactivation.ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	Q99572