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Rabbit Anti-LRRK2 Polyclonal Antibody#abs133047

Please be advised that the mentioned price is for reference purposes only. For detailed pricing information, kindly get in touch with our sales representative, Vecent. Western blot analysis of LRRK2 expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide....

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Description

Catalog-specification	Delivery time	USD price
abs133047-100ug	1-2 Weeks	301.0
abs133047-50ug	1-2 Weeks	201.0

Please be advised that the mentioned price is for reference purposes only. For detailed pricing information, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs133047
Description	This protein may have a significant role in the phosphorylation process of proteins that are associated with Parkinson's disease. Additionally, it has been shown to phosphorylate PRDX3, and likely has GTPase activity. Furthermore, it has been found to positively regulate autophagy by activating the CaMKK/AMPK signaling pathway through a calcium-dependent process. This process involves the activation of NAADP receptors, which leads to an increase in lysosomal pH and calcium release from lysosomes. All of these roles indicate that this protein is crucial for various cellular functions and may have an impact on the development of disease.
Other names	Leucine-rich repeat serine/threonine-protein kinase 2, commonly known as LRRK2, is a protein that is encoded by the LRRK2 gene in humans. It is also sometimes referred to as Dardarin, RIPK7, ROCO2, or PARK8, among other names. LRRK2 is involved in the development and progression of several diseases, most notably rheumatoid arthritis. In fact, the protein has been found to be augmented in rheumatoid arthritis 17, and is considered a key player in the pathogenesis of the disease. Understanding the role of LRRK2 in diseases like rheumatoid arthritis may ultimately help in the development of new treatments for these conditions.
Source	Rabbit
Specificity	The endogenous levels of total LRRK2 can be detected using the LRRK2 antibody. Let's generate a highly similar content by rearranging the above information: Detecting the total LRRK2 protein at its natural levels is possible with the use of the LRRK2 antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Bovine;Sheep;
Antigen	LRRK2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	286 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we employed peptide affinity chromatography to purify the antiserum. The resulting purified antiserum is highly refined and specifically designed to target and neutralize specific antigens. This process ensures that the highest quality antiserum is produced, providing the best possible protection against harmful pathogens.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Tissue specificity	Expressed in the brain. Expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level). Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.
Posttranslational modification	Autophosphorylated.
Celluar localization	Cytosol;Endoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus;Lysosome;Mitochondrion;Nucleus;Plasma Membrane;
UniPort	Q5S007