Phospho-Synuclein-alpha (Tyr133) Rabbit Polyclonal Antibody#abs130913

abs130913-50ug

1-2 Weeks

201

abs130913-100ug

1-2 Weeks

301

Description

The synuclein family consists of alpha-synuclein, beta-synuclein, and gamma-synuclein. These proteins are predominantly found in the brain, and interestingly, alpha- and beta-synuclein exhibit selective inhibition of phospholipase D2.

Other names

Synuclein alpha, also known as alpha-synuclein, is a protein that plays a role in various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. It is encoded by the SNCA gene and exists in different isoforms, including NACP140. Alpha-synuclein is involved in the formation of Lewy bodies, which are abnormal protein deposits found in the brains of individuals with Parkinson's disease.
The protein has various aliases, including alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, NACP, and Non-A beta component of AD amyloid. It is also referred to as the non-A4 component of amyloid precursor and is associated with the pathogenesis of Alzheimer's disease.
Alpha-synuclein is implicated in both autosomal dominant Parkinson's disease (Park 1 and Park 4) and familial Parkinson's disease 1. It is essential to understand the role of alpha-synuclein in neurodegenerative disorders to develop effective treatments and therapies.
Please note that the generated content is not based on the original text information but rearranges the provided content to convey a different message.

Source

Rabbit

Specificity

The antibody Phospho-Synuclein-alpha (Tyr133) specifically recognizes Synuclein-alpha protein that is phosphorylated at Tyrosine 133. This antibody is capable of detecting endogenous levels of phosphorylated Synuclein-alpha. However, it does not recognize the unphosphorylated form of the protein.

Predictive reaction species

Rabbit;Pig;Dog;Horse;Bovine

Application

The recommended dilution for Western blot is between 1:500 and 1:2000, and for ELISA (peptide) it is between 1:20000 and 1:40000. It is important to adhere to these dilution ranges for optimal results in your experiments. To ensure consistency and accuracy, it is advisable to follow the manufacturer's instructions for sample preparation and assay protocols. Additionally, standardizing the dilution process will help minimize variations in data interpretation, leading to more reliable and reproducible outcomes.

The amino acid sequence of a custom-designed peptide is created by synthesizing a portion of human Synuclein-alpha that surrounds Tyrosine 133, a crucial phosphorylation site. To ensure a high degree of similarity, the rearrangement of the provided information focuses on accurately presenting the context of the original text.

Properties

1mg/ml

Purification

The purified rabbit serum was used to extract the antibody, which underwent affinity purification via chromatography performed in sequence on phospho- and non-phospho-peptide affinity columns. A highly similar content can be generated by rearranging the information provided in the original text. It is important to note that the generated content must not be similar to the text produced by the ChapGPT language model, and should be unique in its own right.

Clonality

Polyclonal Antibody

Make sure to maintain a temperature of -20 °C for a period of one year while storing the product. To preserve the quality, avoid subjecting it to repeated cycles of freezing and thawing.

Storage buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

 May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Tissue specificity

Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

Celluar localization

Cytoskeleton;Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Lysosome;Mitochondrion;Nucleus;Plasma Membrane;

P37840