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Rabbit Anti-GP1BB Polyclonal Antibody#abs139279

Description

Catalog-specification	Delivery time	USD price
abs139279-100ug	1-2 Weeks	301.0
abs139279-50ug	1-2 Weeks	201.0

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Overview
catalog	abs139279
Other names	Glycoprotein Ib beta polypeptide, also known as antigen CD42b beta or BDPLT1, plays a crucial role in platelet function. It is a precursor and a subunit of the glycoprotein Ib receptor complex found on platelet surfaces. This complex, composed of GP Ib alpha and GP Ib beta subunits, is involved in the adhesion and activation of platelets. The GP Ib beta polypeptide, encoded by the GP1BB gene, is characterized by the presence of a nuclear localization signal and is associated with the nuclear localization signal deleted in velocardiofacial syndrome. It is a glycoprotein and a vital component of platelet-glycan interactions. Interestingly, this glycoprotein is also referred to as CD42c, BS, GP Ib beta, or GP1bbeta in scientific literature. These different names reflect the multiple facets and roles of this protein in platelet physiology. Overall, the platelet glycoprotein Ib beta polypeptide is an essential component of platelet function and acts in coordination with other subunits to regulate platelet adhesion and activation. Its various names highlight its significance and make it a key target for further research in the field of hemostasis and thrombosis.
Source	Rabbit
Specificity	The GP1BB Antibody is capable of detecting total GP1BB levels present endogenously in a sample. This indicates that the antibody is able to identify the entirety of GP1BB, regardless of its origin or any external factors that may have impacted its expression. It can therefore be a valuable tool for researchers looking to investigate the role of GP1BB in a range of biological processes, as well as for those who are conducting diagnostic tests or treatments for various diseases.
Species Reactivity	Human;Mouse;Monkey
Predictive reaction species	Dog
Antigen	GP1BB
Application	The recommended dilution for Western blotting is 1:1000 to 3000, for immunohistochemistry it is 1:200, and for ELISA using a peptide it is 1:20000 to 1:40000. It is important to use the appropriate dilution for each application to ensure accurate and reliable results. Dilution can impact the sensitivity and specificity of the assay, so it should be optimized for each experiment. With proper dilution and precise techniques, these assays can help to uncover critical insights into various biological processes and pathological conditions.
Immunogen	A synthesized peptide derived from human GP1BB.
MW	22 kDa
Properties
Concentration	1mg/ml
purification	To obtain a purified antiserum, a peptide affinity chromatography technique was employed with the use of SulfoLink™ Coupling Resin. This resin facilitated the purification process, ensuring that the resulting antiserum was of high quality and free from impurities.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the stability of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. To avoid any potential damage to the product, it is important to avoid subjecting it to repeated freeze/thaw cycles. Taking these precautions will help to ensure the product remains effective and usable for its intended purposes.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
Tissue specificity	Expressed in heart and brain.
Celluar localization	Plasma Membrane;
UniPort	P13224