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Rabbit Anti-MOT2 Polyclonal Antibody#abs139153

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Description

Catalog-specification	Delivery time	USD price
abs139153-100ug	1-2 Weeks	301.0
abs139153-50ug	1-2 Weeks	201.0

Overview
catalog	abs139153
Other names	SLC16A7, also known as Monocarboxylate transporter 2 (MCT 2) or MOT2, belongs to the solute carrier family 16 (monocarboxylate transporter) and plays a critical role in transporting monocarboxylates across plasma membranes. This protein facilitates the transport of monocarboxylic acids such as pyruvate and lactate, which are key metabolic intermediates in glycolysis. MCT2 expression is observed in several tissues, including the kidney, brain, and heart. The proper functioning of MCT2 is critical for numerous physiological processes, such as energy metabolism, pH regulation, and lactate uptake and utilization. Dysregulation of MCT2 expression can lead to several diseases, including cancer, neurological disorders and diabetes. Overall, MCT2 is a key player in cellular metabolism and is essential for maintaining cellular homeostasis.
Source	Rabbit
Specificity	The total endogenous levels of MOT2 can be detected by the MOT2 Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	MOT2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MOT2.
MW	52 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	For a period of one year, kindly keep the product wrapped and stored at a temperature of -20 °C. It is important to avoid subjecting the product to repeated cycles of freezing and thawing.
Storage buffer	This product is Rabbit IgG in a solution of phosphate buffered saline at pH 7.4, with a concentration of 150mM NaCl and 0.02% sodium azide. It is also mixed with 50% glycerol to ensure stability. Proper storage of this product requires storage at -20°C. It is recommended to use within 12 months from the date of receipt for optimal results.
Target
Background	Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
Tissue specificity	Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.
Celluar localization	Plasma Membrane;
UniPort	O60669