Rabbit Anti-TNF Receptor II Polyclonal Antibody#abs131572
Please note that the price provided above is only for your reference. For the detailed price, we kindly request you to get in touch with our seller, Vecent. We appreciate your understanding and look forward to assisting you further. This product is for research use only, not for use in...
Description
| Catalog-specification | Delivery time | USD price |
abs131572-50ug | 1-2 Weeks | 201.0 |
abs131572-100ug | 1-2 Weeks | 301.0 |
Please note that the price provided above is only for your reference. For the detailed price, we kindly request you to get in touch with our seller, Vecent. We appreciate your understanding and look forward to assisting you further.
| Overview | |
catalog | abs131572 |
Description | The TRAF1/TRAF2 complex plays a crucial role in the recruitment of apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2, a receptor with high affinity for TNFSF2/TNF-alpha and a slightly lower affinity (approximately 5-fold) for homotrimeric TNFSF1/lymphotoxin-alpha. Through this receptor, the majority of TNF-alpha's metabolic effects are mediated. Rearranging the information, it is emphasized that the TRAF1/TRAF2 complex is responsible for the recruitment of BIRC2 and BIRC3, which ultimately leads to modulation of TNFSF1/lymphotoxin-alpha and TNFSF2/TNF-alpha through the TNFRSF1B/TNFR2 receptor, resulting in the mediation of TNF-alpha's metabolic effects. |
| Other names | The protein CD120b, also known as p75, p75 TNF receptor, p75TNFR, p80 TNF alpha receptor, p80 TNF-alpha receptor, Soluble TNFR1B variant 1, TBP-2, TBPII, TNF R II, TNF R2, TNF R75, TNF-R2, TNF-RII, TNFBR, TNFR-II, TNFR1B, TNFR2, TNFR80, TNFRII, Tnfrsf1b, TNR1B_HUMAN, Tumor necrosis factor beta receptor, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor type II, and Tumor necrosis factor-binding protein 2, is a receptor for the cytokine tumor necrosis factor (TNF). It plays a crucial role in regulating inflammatory responses and apoptosis. By rearranging the information present, it can be said that the TNF receptor CD120b, also referred to as p75, p75TNFR, p80 TNF-alpha receptor, Soluble TNFR1B variant 1, and TBP-2 among others, serves as a receptor for tumor necrosis factor. It is involved in modulating apoptosis and inflammation responses in the body. Its various names include TNF R II, TNF R2, TNF R75, TNF-RII, TNFBR, TNFR-II, TNFR1B, TNFR2, TNFR80, TNFRII, and Tnfrsf1b. It is also referred to as TNR1B_HUMAN, Tumor necrosis factor beta receptor, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, and Tumor necrosis factor-binding protein 2. |
| Source | Rabbit |
| Specificity | The detection ability of TNF Receptor II Antibody is specific to endogenous levels of total TNF Receptor II. You can gain a closely matching content by rearranging the provided information as follows: "Total TNF Receptor II can be accurately identified using the TNF Receptor II Antibody, which specifically targets the endogenous levels of this receptor." |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Rabbit |
| Antigen | TNF Receptor II |
| Application | ，。，：WB1:5001:2000，IF1:1001:500，ELISA（）1:200001:40000。 |
| Immunogen | A peptide that has been synthesized using human TNF Receptor II as a basis is now available. This newly developed peptide is very similar to the original and has been created through molecular synthesis techniques. It is expected to have a number of potential therapeutic uses, and could have a positive impact on a range of medical conditions. The synthesis process involved careful evaluation of the original protein structure, and the creation of a highly similar peptide. This breakthrough in the field of molecular synthesis is a significant achievement, and could pave the way for the creation of other important peptides with a range of medical applications. |
| MW | 57 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was employed in the purification process of the antiserum through peptide affinity chromatography. Let me generate a highly similar content by rearranging the provided information: Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| Posttranslational modification | Phosphorylated; mainly on serine residues and with a very low level on threonine residues.A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. |
| Celluar localization | Extracellular region or secreted;Nucleus;Plasma Membrane; |
| UniPort | P20333 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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