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Rabbit Anti-TLR5 Polyclonal Antibody#abs136095

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Description

Catalog-specification	Delivery time	USD price
abs136095-100ug	1-2 Weeks	301.0
abs136095-50ug	1-2 Weeks	201.0

Overview
catalog	abs136095
Description	The toll-like receptor (TLR) family plays a key role in the recognition of pathogens and initiation of innate immune responses. These receptors identify specific pathogen-associated molecular patterns present on infectious agents. The gene discussed in this text codes for a protein that specifically recognizes bacterial flagellin, which is a key component of bacterial flagella and a virulence factor. Upon activation of this receptor, the nuclear factor NF-kappaB is mobilized, leading to the activation of a range of genes related to inflammation. Mutations of this gene have been linked both to susceptibility and resistance to systemic lupus erythematosus, as well as susceptibility to Legionnaire disease. These findings are based on data provided by RefSeq as of December 2009.
Other names	Toll like receptor 5, also known as TLR5, is a protein that plays a crucial role in the human immune system. The protein is encoded by various genes including FLJ10052, MGC126430, MGC126431, SLEB1, TIL 3, and TIL3. As a Toll-like receptor, TLR5 recognizes and binds to bacterial flagellin. This binding triggers an immune response that aims to eliminate the invading bacteria. TLR5 is also known as Toll/interleukin 1 receptor-like protein 3 (TIR3) and Toll-like receptor 5 precursor. The function of TLR5 is complex and multifaceted, but it is an essential component in the immune system's defense against bacterial infections. Its crucial role in the immune system has made it a target for various researchers trying to develop new treatments and drugs to treat bacterial infections. In conclusion, TLR5 is a critical protein for the human immune system that plays a vital role in protecting the body against bacterial infections. Its importance has made it a popular subject for research, and scientists continue to study it in the hope of developing new treatments for bacterial infections.
Source	Rabbit
Specificity	The total TLR5 present in the body can be easily detected using the TLR5 Antibody. This antibody is capable of detecting endogenous levels of TLR5 without any difficulty. Simply put, it is an effective tool for researchers to study the levels of TLR5 in various samples and draw conclusions from their findings.
Species Reactivity	Human;Mouse;Rat
Antigen	TLR5
Application	For Western Blotting, the recommended dilution range is between 1:500 to 1:2000. When it comes to Immunohistochemistry, a dilution range of 1:50 to 1:200 is recommended. If you are conducting an ELISA test using a peptide substrate, the optimal dilution range is between 1:20000 to 1:40000. Keep in mind that accuracy and precision are key when diluting and using these reagents, so be sure to follow the instructions carefully. These dilution ranges have been established through extensive research and testing, so it is important to adhere to them for reliable results.
Immunogen	A synthesized peptide derived from human TLR5.
MW	98kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Tissue specificity	Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
Posttranslational modification	Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
Celluar localization	Plasma Membrane;
UniPort	O60602