Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-STAM2 Polyclonal Antibody#abs140557

Please note that the price provided is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. In order to generate a highly similar content, make sure to rearrange the given information while maintaining the original context. Western blot analysis...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs140557-100ug	1-2 Weeks	301.0
abs140557-50ug	1-2 Weeks	201.0

Overview
catalog	abs140557
Other names	The gene DKFZp564C047 encodes for a protein called Hbp, also known as Hrs-binding protein or HSE1 homolog. This protein is involved in signal transduction and acts as an adapter molecule with SH3 domain and ITAM motif. Two isoforms of this protein exist, namely STAM2A and STAM2B. STAM2 is a signal transducing adaptor molecule that plays an important role in various cellular processes. It interacts with several proteins, including Hrs, Cbl, and STAM. STAM2 contains SH3 and ITAM domains, which are crucial for its interaction with these proteins. STAM2A and STAM2B are isoforms of STAM2 that arise from alternative splicing of the gene. Both isoforms have similar functions, although STAM2A is more abundantly expressed in the brain, while STAM2B is more widely expressed in other tissues. In summary, STAM2 is an important signal transducing adaptor molecule that plays a critical role in various cellular processes. Its isoforms, STAM2A and STAM2B, have similar functions but are differentially expressed in various tissues.
Source	Rabbit
Specificity	The detection of endogenous levels of total STAM2 is achieved using the STAM2 Antibody. By rearranging the content, a highly similar version can be generated as follows: "Total STAM2 can be accurately identified with the STAM2 Antibody, enabling the detection of its endogenous levels."
Species Reactivity	Human;Mouse;Rat;Monkey
Antigen	STAM2
Application	The optimal dilution ratio for WB is 1:1000, while for IF/ICC it falls between 1:100 and 1:500. As for ELISA using peptide, the recommended dilution ranges from 1:20000 to 1:40000. It's important to note that these dilutions have been determined based on the original text information and should be followed accordingly for accurate results.
Immunogen	A synthesized peptide derived from human STAM2.
MW	58kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for a duration of one year is at -20 °C. It is important to avoid subjecting the stored item to repeated freeze/thaw cycles.
Storage buffer	You can store Rabbit IgG in phosphate buffered saline, pH 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol at a temperature of -20°C for up to 12 months from the day of receipt. It is essential to keep the solution in a highly similar condition to the original text information to ensure its stability. This way, you can maintain the quality of the antibody, ensuring that it works effectively for your research. Remember to handle the solution with care and follow proper storage instructions to avoid contamination or degradation.
Target
Background	Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Tissue specificity	Ubiquitously expressed.
Posttranslational modification	Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Celluar localization	Cytosol;Endosome;Nucleus;
UniPort	O75886