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Rabbit Anti-MAPK13 Polyclonal Antibody#abs132739

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Description

Catalog-specification	Delivery time	USD price
abs132739-100ug	1-2 Weeks	301.0
abs132739-50ug	1-2 Weeks	201.0

Overview
catalog	abs132739
Description	Phosphorylation of downstream targets is elicited in response to environmental stress and pro-inflammatory cytokines activation. It also exerts its influence on protein translation regulation by phosphorylating and subsequently inactivating EEF2K.
Other names	Mitogen-activated protein kinase 13, also known as MAP kinase 13 or p38 delta, is a protein that plays a crucial role in cellular signaling pathways. It is encoded by the gene MK13_HUMAN or MGC99536. This kinase is involved in various cellular processes, including cell growth, differentiation, and apoptosis. It is part of the mitogen-activated protein kinase (MAPK) family, specifically the p38 subfamily. MAP kinase 13 is often referred to as SAPK4 or stress-activated protein kinase 4 due to its involvement in stress response mechanisms. OTTHUMP00000016282 and OTTHUMP00000016283 are other names associated with this protein. Overall, MAP kinase 13 is an important molecule with diverse functions in cellular signaling.
Source	Rabbit
Specificity	The MAPK13 antibody is capable of detecting the total amount of MAPK13 present in the body's natural state. The endogenous levels of this protein can be accurately measured using this antibody. By recognizing the total amount of MAPK13 that is present, researchers are able to gain a better understanding of how this protein functions within the body. This knowledge could be applied to the development of new treatments for a variety of medical conditions.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;
Antigen	MAPK13
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Tissue specificity	Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Posttranslational modification	Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.
Celluar localization	Cytosol;Nucleus;
UniPort	O15264

Western blot analysis of MAPK13 expression in nocodazole treated HCT116 cell lysate; PMA-treated Pam212 cell lysate,The lane on the left is treated with the antigen-specific peptide.

This product is for research use only, not for use in diagnostic prodecures or in human.

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