Rabbit Anti-CDC10 Polyclonal Antibody #abs126993

abs126993-100ul

In Stock

301

Other names

The SEPT7A protein, also known as CDC3p or Cell division control protein 3, plays a crucial role in regulating cell division. Its alternate names include CDC10 and CDC10 protein homolog, as well as Cell division cycle 10. The SEPT7_HUMAN gene encodes for the Septin7 or Septin-7 protein, commonly referred to as Septin 7. This protein belongs to the septin family and is involved in a variety of cellular processes, including cytokinesis and vesicle trafficking. Overall, the SEPT7A protein is essential for proper cell division and functioning.

Source

Rabbit

Specificity

CDC10

Species Reactivity

Human;Mouse;Rat;Cow;Zebrafish;

Application

The dilutions recommended for various assays are as follows: Western blotting (WB) is suggested at a dilution of 1:500-2000. Enzyme-linked immunosorbent assay (ELISA) should be performed at a dilution of 1:500-1000. Immunohistochemistry on paraffin-embedded sections (IHC-P) requires a dilution range of 1:400-800. Immunohistochemistry on frozen sections (IHC-F) should be conducted at a dilution of 1:400-800. For immunofluorescence (IF), the recommended dilution is 1:100-500. It should be noted that paraffin sections necessitate antigen retrieval.

Immunogen

A synthetic peptide derived from human Septin 7, specifically within the fragment of 201-300/437, has been conjugated with KLH. To produce a similar content utilizing the original text information, the synthetic peptide from the human Septin 7 protein within the fragment 201-300/437 has been linked to KLH to create a conjugated compound.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

It is recommended to keep the product stored at a temperature of -20 °C for a period of one year. It is important to take precautions to prevent the product from undergoing repeated freeze and thaw cycles.

Storage buffer

，：

pH7.4，0.01M TBS，1% BSA、0.03% Proclin30050%。

Research area

Cell biology cyclin cell differentiation

Target

Background

The gene in question encodes a protein that bears a striking resemblance to the CDC10 protein found in yeast. Additionally, this protein shares many similarities with proteins found in both Drosophila and mice. Like the yeast CDC10 protein, this human protein features a GTP-binding motif and serves as a crucial component in cytokinesis. In humans, this protein plays a role in gliomagenesis, helping to suppress the growth of glioma cells. It is also necessary for the association of centromere-associated protein E with the kinetochore. Various transcript variants can arise as a result of alternative splicing. Interestingly, researchers have also identified several related pseudogenes in several different chromosomes. These findings have important implications for our understanding of cell biology and the treatment of certain diseases.

Celluar localization

Nucleus cytoplasm

UniPort

Q16181