Rabbit Anti-DUSP26 Polyclonal Antibody #abs127146

ul-100 abs127146
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Dual specificity phosphatase 26 (putative), also known as DSP-4, is a protein that exhibits dual specificity phosphatase activity. It is encoded by the DUSP26 gene and is also referred to as dual specificity phosphatase SKRP3. Another name for this protein is dual specificity protein phosphatase 26 (DUSP24). It is sometimes referred to as hypothetical protein FLJ31142 or NATA1.
The protein is also known as LDP-4 (low molecular mass dual specificity phosphatase 4) or MGC1136. It is also designated as MAP kinase phosphatase 8 (MKP-8) or MKP8. The gene encoding this protein is alternatively designated as MGC2627.
DUSP26 is involved in the regulation of mitogen-activated protein kinases (MAPKs) by dephosphorylating them. This protein has been found to be amplified in thyroid anaplastic cancer, leading to its designation as a novel amplified gene in this disease.
In summary, DUSP26 displays dual specificity phosphatase activity and is involved in the regulation of MAPK signaling. It has been implicated in thyroid anaplastic cancer, where it is amplified. Other names for this protein include LDP-4, MKP-8, and NATA1.

Source

Rabbit

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DUSP26

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The recommended dilutions for WB, ELISA, IHC-P, IHC-F, and IF are as follows: WB (1:500-2000), ELISA (1:500-1000), IHC-P (1:400-800), IHC-F (1:400-800), and IF (1:100-500). It is important to note that antigen retrieval is required for paraffin section in IHC.

Immunogen

KLH conjugated synthetic peptide derived from human DUSP26/MKP8:144-211/211

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Storage buffer

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research area

Tumor Cell Biology Neurobiology Signal Transduction Cyclin Kinase and Phosphatase

Target

Background

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.

Celluar localization

Nucleus cytoplasm