Phospho-CAMKK1/2 (Ser458/495) Rabbit Polyclonal Antibody#abs139965
Just a heads up, the price mentioned is only for your reference. For the right details, kindly reach out to our seller, Vecent. Western blot analysis CAMKK1/2 (Phospho-Ser458/495) using EGF treated 293 whole cell lysates This product is for research use only, not for use in diagnostic prodecures...
Description
| Catalog-specification | Delivery time | USD price |
abs139965-100ug | 1-2 Weeks | 301.0 |
abs139965-50ug | 1-2 Weeks | 201.0 |
Just a heads up, the price mentioned is only for your reference. For the right details, kindly reach out to our seller, Vecent.
| Overview | |
catalog | abs139965 |
| Other names | The Ca2+/calmodulin-dependent protein kinase kinase alpha, also known as Calcium/calmodulin dependent protein kinase kinase, Calcium/calmodulin dependent protein kinase kinase 1 alpha, or simply, Calcium/calmodulin dependent protein kinase kinase 1, is an important player in calcium signaling pathways. It is also referred to as CaM kinase kinase alpha or CaMKK alpha, and is encoded by the CAMKK1 gene. This protein is responsible for activating other important enzymes involved in cellular processes such as growth, differentiation, and survival. It does this by phosphorylating and activating Ca2+/calmodulin-dependent protein kinases, which then go on to phosphorylate and modulate the activity of other downstream targets. Additionally, there is a Calcium/calmodulin-dependent protein kinase kinase 2, also known as CaM kinase kinase beta or CaMKK beta, which is encoded by the CAMKK2 gene. This protein is structurally similar to CaMKK alpha and functions similarly as well, but has different downstream targets and is involved in slightly different processes. Together, CaMKK alpha and beta play crucial roles in maintaining the delicate balance of calcium signals in cells and ensuring proper cellular function. Understanding their mechanisms of action can help in the development of therapeutic interventions for diseases characterized by disrupted calcium signaling, such as cardiac arrhythmia and neurodegenerative disorders. |
| Source | Rabbit |
| Specificity | The CAMKK1/2 (Phospho-Ser458/495) Antibody is designed to detect the presence of CAMKK1/2 protein only when it has been phosphorylated at Ser458/495. This antibody is highly specific and does not cross-react with other proteins, making it an excellent tool for studying the role of CAMKK1/2 in cellular signaling pathways. Researchers can rely on the accuracy of the CAMKK1/2 (Phospho-Ser458/495) Antibody to provide reliable data on the activation of this signaling pathway in various experimental settings. Overall, this antibody is a valuable resource in the exploration of CAMKK1/2 and its functions in cell biology. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep |
| Antigen | CAMKK1/2 |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | CAMKK1/2（Ser458/495）。，。，，ChapGPT。 |
| MW | 64KD |
| Properties | |
Concentration | 1mg/ml |
| purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. |
| Posttranslational modification | Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity). |
| Celluar localization | Cytosol;Nucleus; |
| UniPort | Q8N5S9/Q96RR4 |
Western blot analysis CAMKK1/2 (Phospho-Ser458/495) using EGF treated 293 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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