Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-EPHB1 Polyclonal Antibody#abs131331

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to reach out to our seller, Vecent. Western blot analysis of EPHB1 expression in COS7 cells This product is for research use only, not for use in diagnostic prodecures...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs131331-50ug	1-2 Weeks	201.0
abs131331-100ug	1-2 Weeks	301.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to reach out to our seller, Vecent.

Overview
catalog	abs131331
Other names	Here are some possible options: 1. The receptor known as EPHB1, or Ephrin type B receptor 1, is also referred to by a variety of other names including EK6, ELK, Elkh, Eph tyrosine kinase 2, and EPHT2. It is a member of the EPH family of receptor tyrosine kinases and plays a critical role in neuronal development and plasticity. Another name for this receptor is NET, or Neuronally-expressed EPH-related tyrosine kinase. A soluble variant of the receptor, known as soluble EPHB1 variant 1, has also been identified. 2. EPHB1 is a receptor tyrosine kinase that goes by many names, including EK6, ELK, Elkh, Ephrin type B receptor 1, and Eph tyrosine kinase 2. It is a member of the EPH family and is involved in important processes such as neuronal development and plasticity. Additionally, it is also known as EPHT2, HEK 6, HEK6, NET, or Neuronally-expressed EPH-related tyrosine kinase. There is also a soluble variant of the receptor called soluble EPHB1 variant 1. 3. The tyrosine kinase receptor known as EPHB1, or Ephrin type B receptor 1, is also sometimes referred to as EK6, ELK, Elkh, Eph tyrosine kinase 2, and EPHT2. It is a member of the EPH family and plays an important role in neuronal development and plasticity. Another name for this receptor is NET, or Neuronally-expressed EPH-related tyrosine kinase. Additionally, there is a soluble variant of EPHB1 called soluble EPHB1 variant 1. It is also known as HEK 6, HEK6, and Tyrosine-protein kinase receptor EPH-2. 4. EPHB1, or Ephrin type B receptor 1, is a receptor tyrosine kinase that has several alternative names including EK6, ELK, Elkh, Eph tyrosine kinase 2, and EPHT2. It is a member of the EPH family and plays a crucial role in the development and plasticity of neurons. Another name for this receptor is NET, or Neuronally-expressed EPH-related tyrosine kinase, and there is also a soluble variant of the receptor called soluble EPHB1 variant 1. Some other names for EPHB1 include HEK 6, HEK6, and Tyrosine protein kinase receptor EPH 2. 5. There are many names for the receptor tyrosine kinase EPHB1, including EK6, ELK, Elkh, Ephrin type B receptor 1, and Eph tyrosine kinase 2. It is important for neuronal development and plasticity and is a member of the EPH family. Other names for EPHB1 include EPHT2, HEK 6, HEK6, and NET, or Neuronally-expressed EPH-related tyrosine kinase. Additionally, there is a soluble variant of the receptor called soluble EPHB1 variant 1. Finally, it is also referred to as Tyrosine-protein kinase receptor EPH-2.
Source	Rabbit
Specificity	The EPHB1 Antibody is capable of detecting total EPHB1 levels that occur naturally within the body. This means that the antibody is able to identify and quantify the overall amount of EPHB1 present in a given sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	EPHB1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human EPHB1.
MW	110 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography. Ensuring a highly effective result, this process involved selectively capturing peptides and separating them from other unwanted materials.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store the product for one year at a temperature of -20 °C. Please take care to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity).
Tissue specificity	Preferentially expressed in brain.
Posttranslational modification	Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL.Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation.
Celluar localization	Cytosol;Endoplasmic reticulum;Endosome;Extracellular region or secreted;Plasma Membrane;
UniPort	P54762