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Rabbit Anti-PE2R3 Polyclonal Antibody#abs135181

Description

Catalog-specification	Delivery time	USD price
abs135181-100ug	1-2 Weeks	301.0
abs135181-50ug	1-2 Weeks	201.0

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Overview
catalog	abs135181
Other names	The EP3 receptor, also known as the Prostaglandin E receptor EP3 subtype, is a type of prostanoid receptor. It is encoded by the PTGER 3 gene and is highly expressed in various parts of the body, including the brain, lungs, and kidneys. EP3 receptors are involved in many physiological processes, including inflammation, pain, and fever. When activated by prostaglandin E2 (PGE2), they can constrict blood vessels and decrease blood flow to the affected area, resulting in reduced swelling and pain. There are several isoforms of the EP3 receptor, including EP3 I, II, III, and IV. Each subtype has a slightly different amino acid sequence and may have different effects on cellular signaling and downstream effects. Research has suggested that EP3 receptors may play a role in the development of a number of diseases, including Alzheimer's disease, asthma, and cancer. As a result, there is considerable interest in developing drugs that target the EP3 receptor, either to enhance its activity or to inhibit it. Overall, the EP3 receptor is an important component of the body's response to inflammation and tissue damage. Better understanding of its function and regulation may lead to new treatments for a wide range of diseases.
Source	Rabbit
Specificity	The total PE2R3 levels in the body can be detected with the help of the PE2R3 Antibody, which recognizes the endogenous levels of this protein. To rephrase this information, a possible version could be: The presence of total PE2R3 in the body can be identified using the PE2R3 Antibody, as this reliable tool detects the natural levels of this substance.
Species Reactivity	Human
Antigen	PE2R3
Application	For western blotting, the recommended dilution range is 1:500 to 1:1000. For immunohistochemistry, a dilution of 1:50 to 1:200 is suggested. If conducting immunofluorescence or immunocytochemistry, dilute the antibody at a range of 1:100 to 1:500. Lastly, for ELISA (peptide), a dilution of 1:20000 to 1:40000 is recommended. It's important to note that these dilutions may vary based on the specific experimental conditions and should be optimized by the user.
Immunogen	A synthesized peptide.
MW	40 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography. To ensure a high level of similarity with the original content, the sentence has been rewritten while maintaining the same information.
Clonality	Polyclonal Antibody
Stability & Storage	Please ensure that the product is stored at a temperature of -20 °C for a duration of one year, and it is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).
Tissue specificity	Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	P43115