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Rabbit Anti-FCGR1A Polyclonal Antibody#abs135850

Description

Catalog-specification	Delivery time	USD price
abs135850-100ug	1-2 Weeks	301.0
abs135850-50ug	1-2 Weeks	201.0

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Overview
catalog	abs135850
Description	The immune response is heavily reliant on a crucial protein encoded by this gene. This high-affinity Fc-gamma receptor plays an integral part in the immune system's defense mechanisms. Situated on chromosome 1 are three gene family members, of which this gene is a member. This information was sourced from RefSeq in July of 2008.
Other names	The CD64 molecule is also known as the Fc fragment of IgG high affinity Ia receptor or Fc gamma receptor. It is responsible for binding to the Fc region of immunoglobulin G (IgG) antibodies with high affinity and is expressed on various immune cells, including macrophages, neutrophils, and monocytes. Additionally, CD64A is another variant of this receptor and is also known as Fc gamma RIA. It plays a crucial role in the regulation of immune responses by mediating antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis. Furthermore, FCGR1 or FcgammaRIa is the gene that encodes for the CD64 protein. Its expression is regulated by various cytokines, such as interferon-gamma (IFN-gamma), and is upregulated in response to inflammation or infection. Overall, the CD64 receptor plays a crucial role in the immune system's response to infectious agents. Understanding its function can provide valuable insights into developing immunotherapeutic approaches for treating various diseases.
Source	Rabbit
Specificity	The endogenous levels of total FCGR1A can be accurately detected by the FCGR1A Antibody. A content with a highly similar meaning can be generated by rearranging the above content. We should refrain from using ChapGPT to generate content and instead focus on using a language model to deliver a speech that is completely different from the original text.
Species Reactivity	Human;Mouse;Rat
Antigen	FCGR1A
Application	For Western blot, dilute the antibody at a range of 1:500 to 1:2000. For immunohistochemistry, dilute the antibody at a range of 1:50 to 1:200. For ELISA using peptide, dilute the antibody at a range of 1:20000 to 1:40000. These dilution ranges provide optimal antibody concentration for each assay.
Immunogen	A synthesized peptide derived from human FCGR1A.
MW	43kDa
Properties
Concentration	1mg/ml
purification	Through the implementation of peptide affinity chromatography using SulfoLink™ Coupling Resin, purification of the antiserum was successfully achieved.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Tissue specificity	Monocyte/macrophage specific.
Posttranslational modification	Phosphorylated on serine residues.
Celluar localization	Endosome;Plasma Membrane;
UniPort	P12314