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Rabbit Anti-Ephrin-B3 Polyclonal Antibody#abs140414

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Description

Catalog-specification	Delivery time	USD price
abs140414-100ug	1-2 Weeks	301.0
abs140414-50ug	1-2 Weeks	201.0

Overview
catalog	abs140414
Other names	EFL6, also known as EFNB3 or Ephrin-B3, is a transmembrane ligand that binds to Eph-related receptor tyrosine kinases. Its other aliases include EPLG8, LERK8, and ELK-L3. EFL6 is involved in various biological processes, such as axon guidance, synapse formation, and angiogenesis. It is expressed in various tissues, including the brain, heart, and lung. EFL6 is essential for normal neural development and has been implicated in neurological disorders, such as schizophrenia and Alzheimer's disease. Understanding the role of EFL6 in these conditions may lead to new therapeutic interventions.
Source	Rabbit
Specificity	The total levels of endogenous Ephrin-B3 can be detected by using the Ephrin-B3 antibody. This antibody is specifically designed to identify and bind to the total amount of Ephrin-B3 present within cells. By utilizing this antibody in experiments, researchers can accurately measure the levels of this protein and gain insights into its role in various biological processes.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	Ephrin-B3
Application	The optimal dilutions for WB are 1:1000, and for IF/ICC they range from 1:100 to 1:500. If you are performing ELISA with a peptide, the recommended dilutions are between 1:20000 and 1:40000. It is important to keep these dilutions in mind when performing these assays to achieve accurate and reliable results.
Immunogen	A peptide synthesized from human Ephrin-B3 has been developed that exhibits a high degree of similarity to the original sequence. The peptide, which was derived from the human Ephrin-B3 protein, has been carefully designed to emulate the key structural and functional features of the natural protein. This synthetic peptide offers a versatile tool for studying Ephrin-B3 signaling pathways, as well as for the development of new therapeutic agents that target this important protein. With its high degree of similarity to the original sequence, this synthesized peptide represents a major advance in the field of peptide-based drug discovery and development.
MW	36kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to perform peptide affinity chromatography and purify the antiserum. Let me generate a distinct statement based on the original information.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for this product is at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Tissue specificity	Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
Celluar localization	Plasma Membrane;
UniPort	Q15768