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Rabbit Anti-SCN3A Polyclonal Antibody#abs132643

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Description

Catalog-specification	Delivery time	USD price
abs132643-100ug	1-2 Weeks	301.0
abs132643-50ug	1-2 Weeks	201.0

Overview
catalog	abs132643
Description	The protein plays a crucial role in facilitating the flow of sodium ions across excitable membranes by modulating their voltage-dependent permeability. It responds to changes in membrane voltage by transitioning between open and closed conformations, thereby forming a specific channel that selectively allows Na(+) ions to traverse the membrane in line with their electrochemical gradient.
Other names	The brain III voltage-gated sodium channel, also known as NAC3, Nav1.3, SCN3A, or SCN3A_HUMAN, is a type of sodium channel protein found in the brain. This protein plays a crucial role in neuronal signaling, allowing for the flow of sodium ions across cell membranes. Its primary function is to initiate and propagate action potentials, which are essential for the transmission of electrical signals between neurons. The sodium channel protein type 3 subunit alpha, or sodium channel protein type III subunit alpha, is another name for this protein. Other names for the brain III voltage-gated sodium channel include sodium channel protein, brain III subunit alpha, sodium channel, brain type III, alpha subunit, sodium channel, neuronal type III, alpha subunit, sodium channel, voltage-gated, type III, alpha polypeptide, and sodium channel, voltage-gated, type III, alpha subunit. It can also be referred to as the Voltage gated sodium channel subtype III, or the Voltage gated sodium channel subunit alpha Nav1.3. Overall, the brain III voltage-gated sodium channel is a crucial component of the nervous system and is involved in a variety of physiological processes, including pain perception, learning and memory, and motor control. Understanding the function and regulation of this protein is essential for developing new treatments for neurological disorders such as epilepsy, chronic pain, and Alzheimer's disease.
Source	Rabbit
Specificity	The SCN3A antibody has the capability to detect the total SCN3A levels that exist naturally in the body. By rearranging the information given, a similarly phrased sentence is generated as follows: "Total SCN3A levels present in the body can be identified using the SCN3A antibody."
Species Reactivity	Human
Antigen	SCN3A
Application	The recommended dilutions for using the primary antibody in Western blotting are 1:500-1:2000, while for immunohistochemistry, the recommended dilutions are between 1:50-1:200. For ELISA assays using peptides as antigens, the recommended primary antibody dilutions are 1:20000-1:40000. It is essential to follow the recommended dilutions for the primary antibody to achieve optimal results and avoid non-specific background staining.
Immunogen	A synthesized peptide.
MW	226 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
Posttranslational modification	May be ubiquitinated by NEDD4L; which would promote its endocytosis.Phosphorylation at Ser-1501 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
Celluar localization	Plasma Membrane;
UniPort	Q9NY46