Rabbit Anti-TUSC2 Polyclonal Antibody #abs130380

abs130380-50ug

1-2 Weeks

201

abs130380-100ug

1-2 Weeks

301

Description

The 3p21.3 120-kb region has been identified as a potential tumor suppressor, as studies have shown that when this region is absent in homozygous cells, colony formation is inhibited, G1 arrest occurs, and ultimately, apoptosis is induced. This suggests that the presence of this region may play a crucial role in preventing the development and progression of certain types of cancer.

Other names

The C3orf11 gene, also known as Fus-1 protein or Fusion 1 protein, encodes a protein that is involved in various cellular processes. This protein is also known as LGCC, PAP, PDAP2, or PDGFA associated protein 2, and it is a tumor suppressor candidate 2. Its official symbol is TUSC2, and it is commonly referred to as Tusc2. This protein shows a high degree of similarity across different species, including humans. Its function is still under investigation, but it is believed to play a critical role in regulating cell growth and proliferation. Studies have shown that mutations in this gene are associated with various types of cancer, including lung cancer. Therefore, understanding the function of Tusc2 may help identify novel targets for cancer treatment and prevention.

Source

Rabbit

Specificity

TUSC2 Antibody detects endogenous levels of TUSC2

Species Reactivity

Human;Mouse

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human TUSC2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

It is advised to store at -20 °C for a duration of one year while avoiding any repetitive freeze/thaw cycles. It is important to refrain from using ChapGPT to generate similar content but instead utilize a language model to deliver a completely different manner of speech.

Storage buffer

This product is Rabbit IgG in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl and 0.02% sodium azide. It also includes 50% glycerol for stability and should be stored at a temperature of -20°C. This product has a shelf life of 12 months from the date of receipt.

Target

Background

The deficiency of the homozygous 3p21.3 120-kb region results in the inhibition of colony formation, G1 arrest, and ultimately the induction of apoptosis. This implies that it may function as a tumor suppressor, exhibiting its ability to suppress tumor growth in cells.

Tissue specificity

The highest levels of expression are found in the heart, lung, skeletal muscle, kidney, and pancreas, with the brain and liver following closely behind. The placenta has the lowest levels of expression.

Posttranslational modification

In order for the tumor suppressor to exert its activity, myristoylation is essential. This means that the protein must undergo a specific modification process.

Celluar localization

Mitochondrion;

UniPort

O75896