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Rabbit Anti-LASS4 Polyclonal Antibody #abs130379

Description

Catalog-specification	Delivery time	USD price
abs130379-50ug	1-2 Weeks	201
abs130379-100ug	1-2 Weeks	301

Please note that the price mentioned above is for reference only. For more detailed pricing information, please get in touch with our sales representative, Vecent. It is important to emphasize that the content generated must be based on the original text and should be highly similar, without using the dialogue format of ChapGPT. Instead, please approach the task by generating text using a language model in a completely different manner.

Overview
Description	The protein Lass4 is believed to act either as a genuine dihydroceramide synthase or as a regulator of its functionality. Notably, when this protein is overexpressed in cells, it can participate in the production of sphingolipids that contain distinct fatty acid donors, such as stearoyl- (C18) or arachidoyl- (C20) ceramides. Intriguingly, this process seems to occur independently of the presence of fumonisin B1.
Other names	Ceramide synthase 4, also known as CerS4 or LAG1 homolog ceramide synthase 4, is a protein encoded by the FLJ12089 gene in humans. It is also sometimes referred to as LAG1 longevity assurance homolog 4, LAG1, S. cerevisiae, homolog of, 4, LASS 4, LASS4 LAG1 homolog ceramide synthase 4, LASS4_HUMAN, TRAM homolog 1, Trh 1, or Trh1. The enzyme itself plays an important role in the production of ceramides, which are a type of lipid molecule that play an important role in various cellular processes, including signaling, inflammation, and stress response. Ceramide synthase 4 specifically is involved in the synthesis of longer-chain ceramides, which are important for maintaining the structural integrity of cell membranes. In addition, some studies have suggested that ceramide synthase 4 may also play a role in regulating cell growth and survival. Overall, ceramide synthase 4 is an important protein involved in maintaining cellular homeostasis and responding to various environmental stressors. Its specific functions and mechanisms of action are still being studied, but it is clear that it plays an important role in many aspects of cellular biology and health.
Source	Rabbit
Specificity	LASS4 Antibody detects endogenous levels of LASS4
Species Reactivity	Human
Application	The dilution ratios for Western blot (WB), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA) are as follows: - WB: The dilution range for WB is 1:500 to 1:2000. This means that the primary antibody used in WB should be diluted 500 to 2000 times with the appropriate dilution buffer before use. - IHC: For IHC, the recommended dilution range is 1:50 to 1:200. This indicates that the primary antibody used for IHC needs to be diluted 50 to 200 times with the suitable dilution buffer prior to application. - ELISA: In the case of ELISA using a peptide as the antigen, the optimal dilution range is 1:20000 to 1:40000. This implies that the primary antibody employed in ELISA should be diluted 20000 to 40000 times with the appropriate buffer before performing the assay. Please note that the dilution ratios mentioned above are crucial for achieving accurate and reliable results in WB, IHC, and ELISA experiments.
Immunogen	A synthesized peptide derived from human LASS4
Properties
Concentration	1mg/ml
Purification	Immunogen affinity purified
Clonality	Polyclonal Antibody
Stability & Storage	To ensure preservation, it is recommended to store at a temperature of -20 °C for a period of one year. It is important to note that freezing and thawing cycles should be avoided.
Storage buffer	This solution contains Rabbit IgG in a phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store this solution at a temperature of -20 °C. The solution is stable for a period of 12 months from the date of receipt. Please note that the generated content will be significantly different from the original text and should not follow the format of a conversation.
Target
Background	This protein has the potential to be either a genuine (dihydro)ceramide synthase or a modulator of its activity. When it is overexpressed in cells, it is thought to play a role in the synthesis of sphingolipids that include different fatty acid donors (such as N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides). Surprisingly, this occurs in a fumonisin B1-independent manner. It is speculated that this protein may have an important role in the regulation of sphingolipid metabolism and homeostasis. Further research is needed to determine its exact function and mechanisms of action.
Celluar localization	Endoplasmic reticulum;Nucleus;
UniPort	Q9HA82