Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-PKCB1 Polyclonal Antibody #abs130381

Description

Catalog-specification	Delivery time	USD price
abs130381-50ug	1-2 Weeks	201
abs130381-100ug	1-2 Weeks	301

Please note that the price provided is only for your reference, and for detailed pricing information, please reach out to our sales representative, Vecent. It is important to emphasize that the content generated should be based on the original text information, but rearranged and rephrased to avoid plagiarism. Kindly refrain from using ChapGPT generated content and instead rely on language model generated text that is distinct and unique.

Overview
Description	The RACK protein receptor is encoded by this gene and has been demonstrated to bind to activated protein kinase C beta I in vitro. This protein is also associated with cutaneous T-cell lymphoma and contains two zinc fingers and a bromodomain, indicating its function as a transcriptional regulator. Multiple transcript variants encoding various isoforms have been identified for this gene.
Other names	CTCL tumor antigen se14 3, also known as Cutaneous T cell lymphoma associated antigen se14 3, is a protein encoded by the KIAA1125 gene. It is also referred to as MGC31836, predicted protein of HQ2893, PRKCBP 1, PRO2893, Rack7, Zinc finger MYND domain containing protein 8, or ZMYND 8. This protein is involved in binding to protein kinase C (PKC) and is known as a PKC binding protein 1. It plays a role in various cellular processes and is characterized by the presence of a zinc finger MYND domain. ZMYND8, as it is commonly referred to, has important implications in cutaneous T cell lymphoma and may serve as a potential target for therapeutic interventions.
Source	Rabbit
Specificity	PKCB1 Antibody detects endogenous levels of PKCB1.
Species Reactivity	Human;Mouse
Application	We recommend using the following dilutions for Western Blot: 1:500-1:2000. For Immunofluorescence/Immunocytochemistry, the suggested dilutions are 1:100-1:500. Lastly, for ELISA using peptide antigens, we suggest dilutions of 1:20000-1:40000. It is essential to carefully follow these dilution guidelines to ensure accurate and reliable experimental results.
Immunogen	A synthesized peptide derived from human PKCB1.
Properties
Concentration	1mg/ml
Purification	Purification of the antiserum was achieved through peptide affinity chromatography utilizing SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	It is advisable to store at a temperature of -20 °C for a duration of one year. It is important to prevent the product from going through multiple cycles of freezing and thawing.
Storage buffer	The storage condition for Rabbit IgG is as follows: It should be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This formulation ensures the stability of the antibody for a period of 12 months from the date of receipt.
Target
Background	It appears that this protein could act as a transcriptional corepressor for KDM5D, which is known to down-regulate a variety of metastasis-associated genes. Specifically, it seems to recognize a unique histone signature consisting of H3K4me1-H3K14ac, playing a crucial role in the suppression of prostate cancer cell invasion. By inhibiting KDM5D activity, this protein may function as a potent tumor suppressor, preventing the spread of cancerous cells throughout the body. The precise mechanisms underlying its anti-metastatic effects remain unclear, but further research is likely to shed light on its therapeutic potential in the treatment of metastatic cancer.
Tissue specificity	The gene is detected in all tissues analyzed, but it is predominant in the brain, lung, pancreas, and placenta. Notably, it is also present in cutaneous T-cell lymphomas (CTCL), suggesting its potential involvement in the pathology of this disease.
Celluar localization	Nucleus;
UniPort	Q9ULU4