Rabbit Anti-SRF Polyclonal Antibody #abs130589

abs130589-50ug

1-2 Weeks

201

abs130589-100ug

1-2 Weeks

301

Description

This particular gene is responsible for encoding a nuclear protein that can be found throughout the body, and it has been shown to play a crucial role in both cell proliferation and differentiation. As a member of the MADS box superfamily of transcription factors, this protein is capable of binding to the serum response element (SRE) that is present in the promoter region of various target genes.
By regulating the activity of many immediate-early genes, such as c-fos, this protein is able to exert a significant influence over a number of different cellular processes that are important for normal growth and development. For instance, it has been implicated in cell cycle regulation, apoptosis, cell growth, and cell differentiation, all of which are crucial for the proper functioning of a healthy organism.
Furthermore, this gene is known to be highly responsive to a diverse array of signaling pathways within the body, making it a key downstream target for many different cellular processes. For example, the mitogen-activated protein kinase pathway (MAPK) has been shown to act on this gene through its interactions with the ternary complex factors (TCFs), highlighting the complex and interconnected nature of cellular signaling.

Other names

There are many names associated with the SRF protein, which plays an essential role in regulating gene expression. It is also known as c fos serum response element binding transcription factor, c fos serum response element binding factor, ELK3, ERP, MCM 1, MCM1, OTTHUMP00000039820, and SAP2. These different names reflect the protein's association with various cellular processes and regulatory pathways. Regardless of the name, the SRF protein binds to DNA at specific sites called serum response elements (SREs) to activate or repress gene expression. Many different factors are required for proper SRF function, including various cofactors and post-translational modifications. Overall, the SRF protein is a critical regulator of numerous biological processes and is essential for proper cellular function.

Source

Rabbit

Specificity

SRF Antibody detects endogenous levels of SRF

Species Reactivity

Human;Mouse

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human SRF

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. To avoid any damage, it is advised to avoid freezing and thawing cycles repeatedly. Make sure to follow these storage instructions carefully to ensure the product remains in optimal condition.

Storage buffer

-20°CIgG，pH7.4，150mM，0.02%50%。12。

Target

Background

The serum response element (SRE) is bound by a transcription factor known as SRF, which has an affinity for short DNA sequences of dyad symmetry located about 300 bp upstream of the transcription initiation site of certain genes (e.g. FOS). SRF plays an essential role in cardiac differentiation and maturation, making it a critical element in the development and maintenance of healthy heart function. By regulating the expression of genes associated with cardiac function, SRF helps to ensure that the heart functions optimally in response to a variety of physiological challenges.

Posttranslational modification

Phosphorylated by PRKDC.

Celluar localization

Nucleus;

UniPort

P11831