Rabbit Anti-Metallothionein Polyclonal Antibody #abs122474

abs122474-50ul

In Stock

201

abs122474-100ul

In Stock

301

Other names

Metallothionein is a protein encoded by the CES1 gene and is also known as CES1, Metallothionein 1A, Metallothionein 1S, Metallothionein 2, Metallothionein 2A, Metallothionein IA, Metallothionein II, Metallothionein 2, MGC32848, MT 1A, MT 2, MT2_HUMAN, MT 2A, MT IA, MT II, MT1, MT1A, MT1S, MT2, and MTC. It plays a crucial role in regulating the levels of heavy metals and protecting cells from oxidative stress. Metallothionein 1A and Metallothionein 2 are isoforms of metallothionein that demonstrate similar function. Metallothionein is known for its ability to bind to metals such as zinc, copper, and cadmium, and its expression is often induced in response to heavy metal exposure. This versatile protein is involved in various physiological and pathological processes, including metal homeostasis, detoxification, and immune response. Understanding the functions and regulation of metallothionein can provide valuable insights into the role of metals in human health and disease.

Source

Rabbit

Specificity

Metallothionein

Species Reactivity

Human;Mouse;Rat;

Application

To perform proper immunological assays, it is recommended to use different dilutions for different applications. For ELISA, a dilution of 1:500-1000 should be used, while for IHC-P and IHC-F, a slightly higher dilution of 1:400-800 is recommended. If performing IF, a dilution of 1:100-500 can be used, but it must be noted that paraffin sections require antigen retrieval. These recommendations are crucial for obtaining accurate and reliable results in immunological assays.

Immunogen

mouse metallothionein derived synthetic peptide conjugated with KLH from amino acid position 11 to 61 out of total 61 amino acids is expected to exhibit high similarity to the original sequence.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

-20°C，。/。

Storage buffer

0.01M TBS（pH7.4），1％（BSA），0.03％Proclin30050％。

Research area

、，，。

Target

Background

Metallothioneins (MTs) are a widely distributed group of proteins found in animals, plants, and prokaryotes. These proteins are known for their ability to bind to heavy metal atoms, thanks to their high cysteine content and the absence of aromatic amino acids. In fact, each MT molecule can bind anywhere between 7 and 12 heavy metal atoms. In mammals, the cysteine residues play a crucial role in coordinating heavy metals like zinc, cadmium, and copper through mercaptide linkages. This conservation of cysteine residues ensures MTs' effectiveness in heavy metal detoxification and regulation in various organisms across the animal and plant kingdoms.

Celluar localization

Nucleus cytoplasm

UniPort

Q63871