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Rabbit Anti-FTL Polyclonal Antibody#abs136124

Please note that the price provided above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts of various celllines, using RAD51 antibody. This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs136124-100ug	1-2 Weeks	301.0
abs136124-50ug	1-2 Weeks	201.0

Please note that the price provided above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs136124
Description	The light subunit of the ferritin protein is encoded by this gene, which is responsible for the storage of intracellular iron in both prokaryotes and eukaryotes. This protein is made up of 24 subunits of the heavy and light ferritin chains, and the variation in the composition of these subunits can affect iron uptake and release rates in different tissues. Ferritin's primary function is to store iron in a soluble and non-toxic state. However, defects in this light chain ferritin gene have been linked to several neurodegenerative diseases and hyperferritinemia-cataract syndrome. It is worth noting that this gene has multiple pseudogenes. In summary, the light chain ferritin gene plays a crucial role in the regulation of intracellular iron levels and variations in its subunit composition can have significant effects on iron uptake and release rates. As such, any genetic defects in this gene can lead to serious health implications, including neurodegenerative diseases and hyperferritinemia-cataract syndrome.
Other names	L chain Ferritin; Subunit L Ferritin; Light chain Ferritin; Light polypeptide Ferritin; Ferritin light polypeptide like 3; Human FRIL; FTL; LFTD; NBIA 3; NBIA3. The above content comprises different names or symbols used to refer to the same protein, which is the light chain subunit of the Ferritin molecule. This protein is involved in iron storage and regulation in cells. It is encoded by the FTL gene and mutations in this gene can lead to neurodegeneration with brain iron accumulation (NBIA) type 3.
Source	Rabbit
Specificity	The FTL Antibody is capable of detecting the natural levels of total FTL protein in an organism. This antibody can determine the presence of endogenous FTL.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Pig;Dog;Bovine;Horse
Antigen	FTL
Application	The recommended dilutions for using WB are 1:500-1:2000, for IHC are 1:50-1:200, and for IF/ICC are 1:100-1:500. For ELISA assays using a peptide, a dilution of 1:20000-1:40000 is suggested. It is important to follow these dilution guidelines in order to obtain accurate and reliable results in your experiments. Table of recommended dilutions: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000.
Immunogen	A synthesized peptide derived from human FTL.
MW	19kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography for the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Celluar localization	Cytosol;Extracellular region or secreted;Lysosome;
UniPort	P02792