Rabbit Anti-IRAK3 Polyclonal Antibody #abs130515

abs130515-50ug

1-2 Weeks

201

abs130515-100ug

1-2 Weeks

301

Description

One member of the IRAK family that plays a crucial role in TIR signaling is IRAK3, a TKL kinase. TIRs, which include Toll-like receptors and IL1R family members, rely on IRAKs for efficient signal transduction. IRAK3 is an important mediator in this process, ensuring that TIRs can properly respond to various stimuli. By manipulating the original content, it is possible to generate highly similar yet distinct content that conveys the same message in a novel way.

Other names

Here are some rearranged versions of the provided content:
1. IL-1 receptor-associated kinase M, also known as ASRT5, is an important molecule involved in the signaling pathway of IL-1 receptors.
2. Interleukin 1 receptor associated kinase M, also called IL1 receptor associated kinase M or IRAK-M, plays a crucial role in the functioning of IL-1 receptors.
3. IRAK-3, or Interleukin-1 receptor-associated kinase 3, is another name for IL-1 receptor associated kinase M.
4. Irak3, also known as IL-1 receptor-associated kinase M, is a key component in the IL-1 receptor signaling pathway.
5. The protein IRAK3_HUMAN, also referred to as IL-1 receptor-associated kinase M, plays an important role in IL-1 receptor-mediated signaling events.
Please note that the rearranged content maintains the original information but presents it in different ways.

Source

Rabbit

Specificity

IRAK3 Antibody detects endogenous levels of IRAK3.

Species Reactivity

Human

Application

The dilution range for Western Blot (WB) is typically 1:500 to 1:2000. For Immunohistochemistry (IHC), the recommended dilution is usually 1:50 to 1:200. In the case of Immunofluorescence/Immunocytochemistry (IF/ICC), the suggested dilution range is generally 1:100 to 1:500. Lastly, when performing ELISA using a peptide, it is common to use a dilution of 1:20000 to 1:40000. Please note that these dilutions may vary depending on the specific experiment and the target protein being studied.

Immunogen

A synthesized peptide derived from human IRAK3.

Properties

Concentration

1mg/ml

Purification

Peptide affinity chromatography using SulfoLink™ Coupling Resin was utilized for purifying the antiserum. In this process, the antiserum was subjected to chromatography through peptide affinity columns, which specifically bind to the target antibodies in the antiserum. This resulted in a highly purified antiserum product that was suitable for further analysis and use in various applications. The use of SulfoLink™ Coupling Resin ensured excellent specificity and high yield, making it a valuable tool in the purification of antiserum.

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality of this product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can adversely affect its properties. Therefore, it is advisable to handle the product with care to maintain its stability and ensure that it remains effective throughout its shelf life. Consistent with best practices, proper storage conditions are critical to maximizing the quality and reliability of this product.

Storage buffer

The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at -20 °C. The product is stable for a period of 12 months from the date of receipt. Please note that the generated content is based on the original text information but presented in a different manner.

Target

Background

Either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex, this compound effectively prevents the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex.

Tissue specificity

Mainly found in lymphocytes present in the bloodstream.

Celluar localization

Nucleus;

UniPort

Q9Y616