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Rabbit Anti-GRP75 Polyclonal Antibody #abs130113

Description

Catalog-specification	Delivery time	USD price
abs130113-50ug	1-2 Weeks	201
abs130113-100ug	1-2 Weeks	301

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Overview
Description	HSPA9B is a protein that is involved in regulating cell division and preventing cellular aging. It also has potential chaperone activity. HSPA9B interacts with other proteins such as FXN and HSCB. It is a component of the MINOS/MitOS complex, which comprises of IMMT, HSPA9, and CHCHD3. This complex is associated with mitochondrial outer membrane proteins such as SAMM50, MTX1, and MTX2. HSPA9B is classified as a member of the heat shock protein 70 family.
Other names	The 75 kDa glucose-regulated protein, also known as Grp 75 or Mortalin, is a mitochondrial chaperone protein that plays a crucial role in cellular stress response and protein folding. It is encoded by the HSPA9 gene and has several aliases including CSA, HSPA9A, HSPA9B, PBP74, and MOT. Mortalin is a member of the heat shock protein 70 (HSP70) family and is involved in the transport of proteins to the mitochondria, where they are folded and assembled into functional complexes. It is also known to regulate mitochondrial network dynamics and apoptosis. In addition, Mortalin has been implicated in various diseases and is thought to play a role in cancer progression, neurodegeneration, and aging. Targeting Mortalin has emerged as a potential therapeutic strategy for these conditions, but further research is needed to fully understand its functions and potential clinical applications.
Source	Rabbit
Specificity	Total GRP75 can be detected using the GRP75 antibody at endogenous levels. This means that the antibody has the ability to identify the entirety of GRP75 that is naturally present in a biological sample without the need for external interference.
Species Reactivity	Human;Mouse;Rat;Monkey
Application	Western blotting (WB) is typically performed at dilutions ranging from 1:500 to 1:3000. Immunohistochemistry (IHC) is commonly conducted at dilutions of 1:50 to 1:200. For immunofluorescence/immunocytochemistry (IF/ICC), dilutions in the range of 1:100 to 1:500 are recommended. When performing ELISA using peptides, it is advised to use dilutions of 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human GRP75.
Properties
Concentration	1mg/ml
Purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum through peptide affinity chromatography. The resulting product is highly refined and effective in targeting the desired antigens.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is advised to avoid exposing the product to repeated freeze/thaw cycles during storage.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at a temperature of -20 °C. The IgG should be suspended in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This solution is stable for a period of 12 months from the date of receipt.
Target
Background	Chaperone protein which is implicated in the control of cell proliferation and cellular aging. Plays a role in the erythropoiesis process.
Celluar localization	Extracellular region or secreted;Mitochondrion;Nucleus;
UniPort	P38646