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Rabbit Anti-RALB Polyclonal Antibody#abs139359

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Description

Catalog-specification	Delivery time	USD price
abs139359-100ug	1-2 Weeks	301.0
abs139359-50ug	1-2 Weeks	201.0

Overview
catalog	abs139359
Other names	The RALB_HUMAN gene, also known as 5730472O18Rik or dRalb, codes for a GTP binding protein called Ralb. This protein is a member of the small GTPase family and is involved in regulating intracellular signaling pathways. Ralb is also known by other names such as Ras related GTP binding protein B, Ras-related protein Ral-B, and v ral simian leukemia viral oncogene homolog B. As a GTP binding protein, Ralb plays a crucial role in mediating cellular processes such as cell proliferation, survival, and motility. Dysregulation of Ralb signaling has been implicated in various diseases such as cancer and neuronal disorders. Studies have shown that targeting Ralb activity or its downstream effectors could potentially serve as a therapeutic strategy for these diseases. Therefore, understanding the functions and regulation of Ralb is vital for developing effective treatments. In summary, Ralb is an essential GTP binding protein that plays a crucial role in regulating intracellular signaling pathways. Its dysregulation has been implicated in various diseases, making it a promising therapeutic target.
Source	Rabbit
Specificity	The RALB Antibody is capable of detecting total endogenous levels of RALB. Therefore, it can be used to accurately measure the amount of RALB present in a sample.
Species Reactivity	Human;Mouse;Rat
Antigen	RALB
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RALB.
MW	23 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. A highly refined form of the antiserum was obtained as a result of this process.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal conditions, store for one year at a temperature of -20°C. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The storage for Rabbit IgG is recommended at -20 °C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It has a shelf life of 12 months from the date of receipt.
Target
Background	Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
Posttranslational modification	Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P11234