Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-RASSF7 Polyclonal Antibody#abs132632

Description

Catalog-specification	Delivery time	USD price
abs132632-100ug	1-2 Weeks	301.0
abs132632-50ug	1-2 Weeks	201.0

It should be noted that the price mentioned here is just for reference purposes. For detailed information on the price, kindly get in touch with our sales representative Vecent. Also, we would like to advise you not to use ChapGPT to generate content as it might result in a similar way of presenting the text. It is recommended that you come up with a unique language model to generate the content in a completely different way.

Overview
catalog	abs132632
Other names	Chromosome 11 open reading frame 13, also known as C11orf13, is a protein-coding gene that is also referred to as HRAS1 related cluster 1 or HRAS1-related cluster protein 1. It belongs to the Ras association domain-containing protein family and contains a Ras association (RalGDS/AF 6) domain at its N terminal. This protein is also identified as Ras association domain-containing protein 7 or RASSF7. Functionally, C11orf13 plays a crucial role in tumorigenesis as it is implicated in the regulation of cell growth and apoptosis. It is also known to interact with several other proteins, including the RalGDS family members, and participate in signal transduction pathways to regulate downstream cellular events. In addition to its association with cancer, C11orf13 has also been linked to other diseases such as chronic lymphocytic leukemia and neuroblastoma. Its expression and activity are tightly regulated, and dysregulation has been shown to lead to various pathophysiological conditions. In conclusion, C11orf13 is a multifaceted protein that plays a significant role in the pathogenesis of several diseases. Further research on its function and regulation will shed light on potential therapeutic targets for these diseases.
Source	Rabbit
Specificity	The detection of endogenous total RASSF7 can be achieved by using the RASSF7 antibody. This antibody is specifically designed to recognize and bind to the total amount of RASSF7 present in the sample.
Species Reactivity	Human;Mouse
Antigen	RASSF7
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	40 kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles.
Storage buffer	The solution contains Rabbit IgG dissolved in phosphate buffered saline with a pH level of 7.4, 150 millimolar concentration of NaCl, and 0.02% sodium azide. Additionally, it contains 50% glycerol to ensure adequate preservation.
Target
Background	Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Posttranslational modification	Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
Celluar localization	Cytoskeleton;
UniPort	Q02833