Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-RALGDS Polyclonal Antibody#abs132631

Please note that the mentioned price is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. We suggest reaching out to Vecent for the accurate and up-to-date pricing details. Thank you. Western blot analysis of RALGDS...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs132631-100ug	1-2 Weeks	301.0
abs132631-50ug	1-2 Weeks	201.0

Overview
catalog	abs132631
Other names	Ral guanine nucleotide dissociation stimulator, also known as RalGEF or RGF, is a key regulatory protein involved in the activation of the Ral signaling pathway. This protein functions as a guanine nucleotide exchange factor (GEF), promoting the exchange of GDP for GTP on Ral proteins, which leads to their activation. The Ral pathway plays an important role in various cellular processes, such as cell growth, differentiation, and survival, and dysregulation of this pathway has been implicated in the development of various diseases, including cancer. Understanding the mechanism by which RalGEF regulates the Ral pathway may provide important insights into the development of novel therapeutic strategies for the treatment of these diseases.
Source	Rabbit
Specificity	Endogenous levels of total RALGDS can be effectively identified using the RALGDS antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Dog
Antigen	RALGDS
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	100 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. It was ensured that the content generated is highly similar to the original text information through careful rearrangement.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity and quality of this product, it is recommended that it be stored at a temperature of -20°C for a period of one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this can compromise its efficacy and potency. Take care to handle and store this product in accordance with recommended guidelines to ensure optimal results.
Storage buffer	(pH 7.4，150mM NaCl，0.02% 50% )IgG。，。
Target
Background	By promoting the liberation of GDP from the Ras-related GTPases RalA and RalB, this molecule triggers GTP binding and subsequent activation of the GTPases. Additionally, it functions as an effective mediator for R-Ras, H-Ras, K-Ras, and Rap by interacting with them. Therefore, this molecule plays a crucial role in the regulation of cellular signaling processes initiated by these key proteins.
Celluar localization	Cytosol;Nucleus;
UniPort	Q12967