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Rabbit Anti-RRAGD Polyclonal Antibody#abs139332

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Description

Catalog-specification	Delivery time	USD price
abs139332-100ug	1-2 Weeks	301.0
abs139332-50ug	1-2 Weeks	201.0

Overview
catalog	abs139332
Other names	Rag D, also known as Ras-related GTP binding D or RRAGD, is a protein encoded by the gene BA11D8.2.1, also known as DKFZp761H171 or FLJ44176. It is an essential component in the regulation of mTORC1 activity and is involved in the amino acid sensing pathway. The protein plays a crucial role in the development and progression of various diseases, and is a promising therapeutic target for preventing or treating these disorders. Rag D is a member of the Ras-related GTP-binding protein family, which is involved in the regulation of various cellular processes such as cell growth, differentiation, and survival. It functions as a molecular switch, cycling between an inactive GDP-bound state and an active GTP-bound state, and interacts with other proteins to mediate downstream signaling pathways. Studies have shown that Rag D is highly expressed in various cancer cells, and its overexpression is associated with increased cell proliferation, invasion, and metastasis. Inhibition of Rag D activity has been shown to suppress tumor growth and improve the response to chemotherapy in preclinical models. Furthermore, mutations in the RRAGD gene have been linked to the development of various neurological disorders, such as autism and intellectual disability. Understanding the molecular mechanisms underlying RRAGD-related diseases may lead to the development of novel therapeutic strategies to improve patient outcomes. In summary, Rag D is a critical protein involved in various cellular processes and plays a crucial role in the development and progression of several disorders. Further research on the molecular mechanisms of Rag D may lead to the discovery of new therapeutic targets for the treatment of these diseases.
Source	Rabbit
Specificity	The RRAGD Antibody is capable of detecting the total amount of endogenous RRAGD present in the body. The levels of RRAGD can be detected accurately using this antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	RRAGD
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RRAGD.
MW	46 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography employing SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store the product at a temperature of -20 °C for a period of one year. It is important to avoid exposing it to repeated freeze and thaw cycles, as this could compromise its effectiveness.
Storage buffer	The storage of Rabbit IgG in phosphate buffered saline is crucial for its preservation and efficacy. A pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol are all necessary components for maintaining the stability of this product. Proper storage should occur at -20 °C and be monitored regularly to ensure the product remains viable and effective. It is recommended to use the product within 12 months from the date of receipt to ensure maximum potency. Failure to store Rabbit IgG properly could result in decreased effectiveness and increased risk of contamination.
Target
Background	Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.
Celluar localization	Cytoskeleton;Cytosol;Endosome;Lysosome;Nucleus;
UniPort	Q9NQL2