Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-TGFR2 Polyclonal Antibody #abs130195

Please note that the price provided above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Data Examples Western blot analysis on NIH-3T3 cell lysate using TGFR2 Antibody This product is for research use only, not for use in diagnostic...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs130195-50ug	1-2 Weeks	201
abs130195-100ug	1-2 Weeks	301

Please note that the price provided above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
Description	TGFBR2 is a member of the serine/threonine-protein kinase receptor (STKR) family and acts as a TKL kinase. It plays a crucial role in the dimerization of TGF-beta receptors R1 and R2 upon binding TGF-beta at the cell surface. Additionally, TGFBR2 has a specific affinity for the protein DAXX. Interestingly, defects or abnormalities in TGFBR2 have been linked to the development of esophageal cancer. These findings highlight the significance of maintaining the proper functioning of TGFBR2 in cellular processes and underscore its potential as a therapeutic target for combating esophageal cancer.
Other names	II Transforming growth factor beta receptor; growth factor receptor type II Transforming beta; II receptor beta type Transforming growth factor; beta receptor Transforming growth factor type II receptor beta; receptor Transforming growth factor beta receptor type II; growth factor receptor type II Transforming beta; receptor Transforming growth factor beta receptor II type; beta receptor Transforming growth II factor type; receptor beta Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth type II factor receptor II Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth type II factor receptor II Transforming beta; receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth factor II receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth type II factor receptor II Transforming beta; receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth type II factor receptor II Transforming beta; receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth type II factor receptor II Transforming beta; receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth type II factor receptor II Transforming beta; receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth factor II receptor type Transforming beta; receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; II receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth II factor receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth factor II receptor type beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming growth II factor type receptor beta Transforming; beta receptor Transforming growth factor receptor II type Transforming beta; receptor Transforming growth II factor receptor type Transforming beta; receptor Transforming growth factor receptor II type Transforming beta; II receptor Transforming growth factor II receptor type Transforming; beta receptor Transforming growth factor receptor II type beta Transforming; beta receptor Transforming
Source	Rabbit
Specificity	Endogenous levels of total TGFR2 can be detected using the TGFR2 antibody. The antibody is designed to recognize and bind to the total TGFR2 protein present in the sample, indicating the presence of the protein. This highly specific antibody can be used in various research applications to investigate the role and function of TGFR2 in different biological processes and diseases. By measuring the levels of TGFR2, researchers can gain valuable insights into the underlying mechanisms that regulate cell signaling and communication, leading to a better understanding of complex biological systems.
Species Reactivity	Human;Mouse;Rat
Application	The recommended dilutions for Western Blot range from 1:500 to 1:3000. For IF/ICC, the ideal dilutions are 1:100 to 1:500. When performing an ELISA assay using peptide, the suggested dilutions are 1:20000 to 1:40000. It is important to adhere to these recommended dilutions to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human TGFR2.
Properties
Concentration	1mg/ml
Purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography. The process involved rearranging the original content to ensure the generation of a highly similar statement.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure preservation, it is recommended to store at a temperature of -20 °C for a period of one year. To maintain the quality, it is important to avoid subjecting the item to multiple freeze and thaw cycles during this time.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the antibody is guaranteed for 12 months from the date of receipt.
Target
Background	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Posttranslational modification	Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P37173