Rabbit Anti-TGF Beta2 Polyclonal Antibody #abs130196

abs130196-50ug

1-2 Weeks

201

abs130196-100ug

1-2 Weeks

301

Description

TGF-beta 2, also known as TGFB2, exhibits suppressive effects on T-cell growth that is dependent on interleukin-2. It functions as a homodimer, linked by disulfide bonds. Notably, it has been observed to form heterodimers with TGFB1 and TGFB3 within the bone. Furthermore, TGFB2 interacts with the serine proteases HTRA1 and HTRA3, as well as with ASPN. It belongs to the TGF-beta family and undergoes alternative splicing to generate two isoforms in humans.

Other names

Transforming growth factor beta, also known as TGF beta or TGFB, is a protein that plays a crucial role in cell growth inhibition and tumor suppression. It is encoded by several genes, including TGFB1, TGFB2, and TGFB3. Other names for this protein include ARVD, CED, Polyergin, and LAP.
TGF beta is known to regulate many cellular processes, including differentiation, proliferation, and apoptosis. It can also function as an immune suppressor, especially in the case of Glioblastoma derived T cell suppressor factor (GTSF).
Latency-associated peptide (LAP) is a binding partner of TGF beta that enhances its stability and controls its release. In addition, the DPD1 gene is also associated with TGF beta signaling.
Overall, TGF beta is a complex protein with a diverse array of functions. It is essential for regulating normal cellular processes and protecting against cancer, but it can also contribute to tumor progression under certain conditions. As such, understanding the intricacies of TGF beta signaling remains a critical area of research in cancer biology.

Source

Rabbit

Specificity

The levels of endogenous TGF beta2 can be detected using the TGF beta2 Antibody. To generate similar content, the text can be rearranged as follows: The TGF beta2 Antibody is capable of identifying the natural levels of TGF beta2 present within the body.

Species Reactivity

Human;Mouse;Rat

Application

The recommended dilution for immunohistochemistry is 1:50-1:200, for Western blotting is 1:1000, and for ELISA (peptide) it ranges from 1:20000-1:40000. Please note that this rearranged content maintains the original information but is presented in a different manner.

Immunogen

A synthesized peptide derived from human TGF beta2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To maintain optimal conditions, store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the item to multiple freeze/thaw cycles. Please refrain from using the ChapGPT dialogue generation method and instead, focus on generating a completely distinct narrative using the language model.

Storage buffer

-20°CIgG，pH7.4，150mMNaCl，0.02%50%。12。，，。

Target

Background

Interleukin-2 dependent T-cell growth is inhibited by the suppressive effects of TGF-beta 2. The presence of TGF-beta 2 hampers the growth of T-cells that rely on interleukin-2 for their expansion.

Posttranslational modification

，TGF-beta-2LAP。TGF-beta-2LAP，。，。

Celluar localization

Extracellular region or secreted;

UniPort

P61812