Rabbit Anti-TGFB3 Polyclonal Antibody #abs130197

abs130197-50ug

1-2 Weeks

201

abs130197-100ug

1-2 Weeks

301

Description

TGFB3 is a member of the TGF-beta family and plays a crucial role in embryogenesis and the differentiation of cells. It functions as a homodimer, wherein two identical TGFB3 molecules are linked together by disulfide bonds. Furthermore, TGFB3 interacts with ASPN, another protein involved in various biological processes.

Other names

Transforming growth factor beta 3, also known as TGF beta 3, is a protein that plays a crucial role in cell differentiation and proliferation. It is encoded by the ARVD1 gene, also known as LDS5, FLJ16571, RNHF, MGC105479, and MGC118722. TGF beta 3 is synthesized as a precursor protein, prepro-transforming growth factor beta-3, which undergoes several post-translational modifications to become the active protein. It is involved in various biological processes such as embryonic development, wound healing, and immune regulation. Dysregulation of TGF beta 3 has been associated with several diseases, including cancer, fibrosis, and cardiovascular disorders. Understanding the mechanisms through which TGF beta 3 exerts its effects can provide insights into the development of novel therapeutics to treat these diseases.

Source

Rabbit

Specificity

The TGFB3 antibody is effective in identifying the total amount of endogenous TGFB3 in samples. This means that the antibody can detect and measure the levels of TGFB3 present in a given system. The antibody is sensitive and specific and can provide accurate results. Utilizing this antibody in research can help to better understand the role of TGFB3 in biological processes and disease states.

Species Reactivity

Human;Mouse;Rat;Monkey

Predictive reaction species

Chicken;Sheep;Dog;Horse;Bovine

Application

，。 WB: 1:500~1:3000，IHC: 1:50~1:200，IF/ICC: 1:100-1:500，ELISA（）: 1:20000-1:40000。

Immunogen

A synthesized peptide derived from human TGFB3.

Properties

Concentration

1mg/ml

Purification

SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.

Clonality

Polyclonal Antibody

Stability & Storage

The recommended storage condition for this product is at -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.

Storage buffer

This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its integrity, it is recommended to store it at -20°C, and it is stable for up to 12 months from the date of receipt.

Target

Background

Cell differentiation and embryogenesis are closely connected processes. Embryogenesis refers to the development of an organism from a fertilized egg, and it involves a series of coordinated cellular events that result in the formation of various tissues and organs. During this process, differentiating cells undergo specific changes in gene expression and function, leading to the establishment of distinct cell types with specialized roles. The mechanisms and signals involved in embryogenesis are highly intricate and tightly regulated, ensuring the proper development and functioning of the organism. Understanding the factors and processes involved in embryogenesis and cell differentiation is crucial for gaining insight into developmental disorders and for advancements in regenerative medicine.

Posttranslational modification

The process of producing mature TGF-beta-3 involves the splitting of its precursor molecule into two parts: the active TGF-beta-3 protein and the LAP protein, which remains attached to it but serves to inhibit its action. This non-covalent linkage keeps the TGF-beta-3 molecule in an inactive state until it is needed for its intended biological function. Overall, this mechanism provides a means to regulate the activity of TGF-beta-3 in the body and ensures that it is delivered to the correct target cells at the appropriate time.

Celluar localization

The secreted extracellular region, nucleus, and plasma membrane are all critical components of a cell. The extracellular region is responsible for communication between cells, while the nucleus contains genetic material and controls cellular functions. The plasma membrane acts as a barrier, allowing only certain substances to enter or exit the cell. These areas play vital roles in maintaining proper cellular function and communication within the body.

UniPort

P10600