Rabbit Anti-Cyclin G Polyclonal Antibody #abs130082

abs130082-50ug

1-2周

￥1100.00

abs130082-100ug

1-2周

￥1650.00

Description

CCNG1, a member of the cyclin family, may have a pivotal role in the regulation of cellular growth. It has been shown to induce G2/M phase arrest in response to DNA damage, suggesting its involvement in the maintenance of genomic stability. Furthermore, it has been suggested that CCNG1 may act as an intermediary in the inhibitory role of p53 on cellular proliferation. Interestingly, CCNG1 has been found to be activated in breast and prostate cancer cells, indicating its potential as a therapeutic target. Activation of CCNG1 has also been observed following treatment with actinomycin-D, a DNA damage-inducing agent, further highlighting its potential involvement in the repair of damaged DNA.

Other names

CCNG1, also known as Cyclin G1 or Cyclin-G, is a human protein encoded by the CCNG1 gene. It plays a role in the regulation of cell cycle progression. With its functions, CCNG1 is an essential molecule involved in controlling cell division and growth. Additionally, CCNG1 is implicated in various cellular processes, including DNA damage response, cell aging, and cell death. Understanding the mechanisms and functions of CCNG1 can provide insights into the development and progression of diseases such as cancer. In summary, CCNG1 is a significant protein that has implications in various cellular activities and can serve as a potential target for therapeutic interventions.

Source

Rabbit

Specificity

The endogenous levels of total Cyclin G can be effectively detected using an antibody specific to Cyclin G.

Species Reactivity

Human;Mouse;Rat

Predictive reaction species

Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;

Application

The recommended dilutions for Western blot (WB) range from 1:500 to 1:3000. For immunohistochemistry (IHC), the suggested dilutions are between 1:50 and 1:200. When it comes to immunofluorescence/immunocytochemistry (IF/ICC), the appropriate dilutions range from 1:100 to 1:500. Lastly, for ELISA using a peptide, the dilutions should be within the range of 1:20000 to 1:40000.

Immunogen

A synthesized peptide derived from human Cyclin G.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. A highly comparable statement to the original text can be generated by rearranging the wording without altering the overall meaning of the content.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to prevent any freeze/thaw cycles from occurring repeatedly.

Storage buffer

This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, along with 150mM NaCl and 0.02% sodium azide, and has been supplemented with 50% glycerol to ensure long-term stability. For optimal results, it is recommended to store this solution at a temperature of -20 °C. The solution is guaranteed to remain stable for a period of 12 months from the date of receipt, provided that the recommended storage conditions are followed.

Target

Background

This protein is believed to be involved in the regulation of growth. It has been found to be associated with the arrest of the cell cycle in G2/M phase in response to DNA damage. It is possible that this protein may be an intermediate molecule involved in the pathway by which p53 inhibits cellular proliferation. This protein has been shown to play a crucial role in maintaining cell cycle checkpoints, which are essential for the proper regulation of cell division and growth. The exact mechanisms by which this protein mediates its actions are still being studied, but it is clear that it represents an important target for the development of novel cancer therapies.

Tissue specificity

High levels in skeletal muscle, ovary, kidney and colon.

Celluar localization

Nucleus;

UniPort

P51959