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Rabbit Anti-AGT Polyclonal Antibody#abs137453

Please be advised that the price mentioned above is only for your reference. For specific and detailed pricing information, we recommend reaching out to our seller, Vecent. Western blot analysis AGT using K562 whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs137453-50ug	1-2 Weeks	201.0
abs137453-100ug	1-2 Weeks	301.0

Please be advised that the price mentioned above is only for your reference. For specific and detailed pricing information, we recommend reaching out to our seller, Vecent.

Overview
catalog	abs137453
Other names	Angiotensinogen (serpin peptidase inhibitor clade A member 8), also known as AGT or AI265500, is a protein that plays a crucial role in the renin-angiotensin system. It is responsible for the production of angiotensin I (Ang I), which is subsequently converted to angiotensin II (Ang II) by the action of an enzyme called angiotensin-converting enzyme (ACE). Ang II is a potent vasoconstrictor that regulates blood pressure and fluid balance in the body. It also stimulates the release of aldosterone, a hormone that regulates salt and water balance. Ang II has been implicated in various cardiovascular diseases, including hypertension and heart failure. In addition to its role in the production of Ang II, angiotensinogen may have other functions as well. It has been suggested that it may act as an inhibitor of certain enzymes, such as trypsin, and play a role in immune response regulation. Angiotensinogen is produced mainly in the liver and is released into the bloodstream. It can be cleaved by the enzyme renin to yield Ang I, which is subsequently converted to Ang II. The activity of angiotensinogen is tightly regulated, and its dysregulation has been associated with several pathological conditions. Overall, angiotensinogen is a crucial player in the renin-angiotensin system and is involved in the regulation of blood pressure, fluid balance, and immune response. Further research is needed to fully understand its functions and potential therapeutic implications.
Source	Rabbit
Specificity	The AGT Antibody is specifically designed to recognize and quantify the levels of total AGT naturally present in the body.
Species Reactivity	Human;Mouse
Antigen	AGT
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human AGT.
MW	53 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography. To achieve highly purified antiserum, this method was utilized.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition is at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the stored item to multiple freeze/thaw cycles.
Storage buffer	This is a product containing Rabbit IgG suspended in phosphate buffered saline at pH 7.4, with the addition of 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to be stored at a temperature of -20°C for optimal preservation and stability, and has a shelf life of 12 months from the date of receipt.
Target
Background	Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Tissue specificity	Expressed by the liver and secreted in plasma.
Posttranslational modification	Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
Celluar localization	Cytosol;Extracellular region or secreted;
UniPort	P01019