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Rabbit Anti-INPP4B Polyclonal Antibody#abs137452

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Description

Catalog-specification	Delivery time	USD price
abs137452-100ug	1-2 Weeks	301.0
abs137452-50ug	1-2 Weeks	201.0

Overview
catalog	abs137452
Other names	4-Phosphatase, type II inositol polyphosphate; Type II inositol-3,4 bisphosphate 4-phosphatase; 4-bisphosphate 4-phosphatase; Inositol polyphosphate 4-phosphatase type II; Inositol polyphosphate 4-phosphatase type II 105 kDa; INP4B_HUMAN; Inpp4b; MGC132014; Type II inositol 3,4 bisphosphate 4 phosphatase; Type II inositol polyphosphate 4 phosphatase. Type II Inositol Polyphosphate 4 Phosphatase, also known as 4-Bisphosphate 4-Phosphatase, is an enzyme involved in the intracellular signaling pathways. As its name implies, it functions by dephosphorylating inositol polyphosphates, specifically inositol 3,4- bisphosphate, to generate inositol 3-phosphate. This enzymatic reaction is significant in regulating various cellular processes such as cell growth, proliferation, and vesicular trafficking. The Type II Inositol Polyphosphate 4 Phosphatase is known to have a molecular weight of approximately 105 kDa. It is encoded by the INPP4B gene in humans and is commonly referred to as INPP4B. This gene plays a crucial role in maintaining cellular homeostasis by controlling the levels of inositol polyphosphates. Mutations or dysregulation in the INPP4B gene have been associated with various diseases, including cancer and metabolic disorders. Furthermore, this enzyme has emerged as a potential therapeutic target for the development of novel drug interventions. In conclusion, the Type II Inositol Polyphosphate 4 Phosphatase is a key enzyme in the regulation of inositol polyphosphates and is involved in fundamental cellular processes. Understanding its mechanisms and potential clinical implications can pave the way for advancements in disease treatment and therapeutic strategies.
Source	Rabbit
Specificity	The expression of total INPP4B can be detected using the INPP4B Antibody, which is capable of recognizing the endogenous levels of this protein.
Species Reactivity	Human
Predictive reaction species	Zebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
Antigen	INPP4B
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human INPP4B.
MW	107 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography for purification purposes. To ensure the highest level of purity, this process was employed.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze and thaw cycles as this may affect the integrity of the product. So, it is advised to handle the product carefully and follow the storage instructions properly.
Storage buffer	This product is Rabbit IgG that has been formulated in a solution containing phosphate buffered saline at a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. Additionally, the solution contains 50% glycerol which serves as a stabilizing agent. For optimal performance, it is recommended that this product is stored at a temperature of -20 °C. This product has a shelf life of 12 months from the date of purchase, allowing for long-term storage and use in a variety of applications.
Target
Background	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.
Tissue specificity	Widely expressed with highest levels occurring in the skeletal muscle and heart.
Celluar localization	Cytosol;
UniPort	O15327