Phospho-Tau (Ser214) Rabbit Polyclonal Antibody#abs130769

abs130769-50ug

1-2 Weeks

201

abs130769-100ug

1-2 Weeks

301

Description

The microtubule-associated protein tau (MAPT) is encoded by this specific gene, and its transcript can undergo complex and regulated alternative splicing. Consequently, several mRNA species are produced. These MAPT transcripts display a differential expression pattern in the nervous system, depending on the neuron type and stage of neuronal maturation.

Other names

Some possible rearranged sentences based on the original text:
- Microtubule-associated protein tau, also known as MAPT or TAU, is a key factor involved in neurofibrillary tangle formation, a pathological hallmark of Alzheimer's disease and related tauopathies.
- Tau is encoded by the MAPT gene and plays a crucial role in stabilizing microtubules, which are important for cell shape, movement, and transport.
- Abnormal tau proteins can undergo various post-translational modifications and misfold into pathological aggregates, such as paired helical filaments (PHFs), that disrupt neuronal function and cause neurodegeneration.
- Tau pathology has been linked to diverse clinical presentations, including cognitive impairment, motor dysfunction, and even respiratory failure in some cases.
- Besides its cytoskeletal and pathological roles, tau has been shown to interact with a variety of proteins, such as G protein beta/gamma subunits and protein phosphatase 1 regulatory subunit 103 (PPP1R103), which may modulate its function and localization.
- There are multiple isoforms of tau, resulting from alternative splicing and differential exon usage, which may have distinct properties and pathological consequences.
- Understanding the complex biology of tau and its dysregulation in various disorders is a major challenge for current research and may pave the way for novel diagnostic and therapeutic strategies.

Source

Rabbit

Specificity

The Phospho-Tau (Ser214) Antibody is capable of detecting the presence of Tau in the body only when it has been phosphorylated specifically at Serine 214. This means that the antibody is highly specific in its targeting and can be used to track the levels of Tau in the body during various physiological processes. By using this antibody, researchers can gain insights into the role of Tau in neurodegenerative diseases and other conditions where Tau has been implicated. Overall, the Phospho-Tau (Ser214) Antibody is a powerful tool for studying the intricate workings of the human brain and unlocking the mysteries of neurological disorders.

Predictive reaction species

Chicken;Rabbit;Pig;Dog;Bovine;Horse;

Application

WB1:5001:2000，IHC1:501:200，ELISA()1:200001:40000。。

A peptide composed of human Tau and centered around Serine 214, where phosphorylation occurs, has been successfully synthesized. The synthesized peptide closely resembles the original text information.

Properties

1mg/ml

Purification

The purified rabbit serum was used to extract the antibody, which was further purified using affinity purification techniques involving sequential chromatography on phospho- and non-phospho-peptide affinity columns. This resulted in a highly pure and concentrated antibody sample, ready for use in various experiments and assays.

Clonality

Polyclonal Antibody

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is advised to avoid subjecting the product to repeated freezing and thawing cycles to avoid any potential damage to its properties.

Storage buffer

This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal performance, store at -20°C and it will remain stable for up to 12 months from the date of receipt.

Target

Background

 Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Tissue specificity

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Celluar localization

Cytoskeleton;Cytosol;Nucleus;Plasma Membrane;

P10636