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Rabbit Anti-Cardiotrophin-1 Polyclonal Antibody#abs138033

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Description

Catalog-specification	Delivery time	USD price
abs138033-100ug	1-2 Weeks	301.0
abs138033-50ug	1-2 Weeks	201.0

Overview
catalog	abs138033
Other names	Cardiotrophin 1, also known as CT-1 or cardiophin1, is a protein that plays a crucial role in the regulation of heart function. It is also referred to as Cardiotrophin I, Cardiotrophin-1, or CTF1. The human gene for CT-1 is located on chromosome 16q22.1. CT-1 is a member of the interleukin-6 cytokine family and is primarily produced by cardiac muscle cells. CT-1 functions as a regulator of cardiac myocyte growth and survival and also has cardioprotective effects in various heart diseases. The therapeutic potential of CT-1 has been explored in pre-clinical studies as a potential treatment for heart failure. Further research is needed to fully understand the mechanisms of action of CT-1 and its potential as a therapeutic target.
Source	Rabbit
Specificity	The Cardiotrophin-1 Antibody is capable of detecting total Cardiotrophin-1 levels that are present within the body. This antibody is designed to work specifically against endogenous Cardiotrophin-1, which means that its detection capabilities are highly accurate. By detecting the total levels of Cardiotrophin-1 within the body, this antibody helps researchers to better understand the role that this protein plays in various biological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	Cardiotrophin-1
Application	The recommended dilution ratios for WB, IHC, and ELISA vary based on the assay type. For WB, a dilution of 1:1000-3000 is recommended, while a dilution of 1:200 is optimal for IHC. ELISA using a peptide substrate should be diluted at a rate of 1:20000-1:40000. It is important to carefully follow the recommended protocols and dilution ratios to ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide that has been created using human Cardiotrophin-1 provides an effective solution for several medical conditions. This peptide has been designed to mimic the function of Cardiotrophin-1, which is a cytokine protein that plays an important role in the growth and differentiation of various tissues. By developing a synthesized peptide that is derived from this protein, researchers have been able to create a therapeutic agent that can modulate cellular responses and regulate the immune system. This approach has led to the development of several drug candidates that are currently being evaluated for their clinical use in treating a range of diseases. These include various forms of cancer, cardiac disorders, and autoimmune diseases. With ongoing research and development in this field, the potential applications of Cardiotrophin-1-derived peptides continue to expand, highlighting their significance in modern medicine.
MW	21 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal preservation, it is recommended to keep the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, which may compromise its quality.
Storage buffer	This Rabbit IgG comes in a phosphate buffered saline solution with a pH of 7.4, containing 150mM NaCl and 0.02% sodium azide. It also has 50% glycerol added to it which helps with storage at -20°C. This solution maintains its stability for up to 12 months from the date of receipt. Please make sure to handle it carefully and avoid any potential contamination.
Target
Background	Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Tissue specificity	Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.
Celluar localization	Extracellular region or secreted;
UniPort	Q16619