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Rabbit Anti-Calcitonin Polyclonal Antibody#abs138032

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Description

Catalog-specification	Delivery time	USD price
abs138032-100ug	1-2 Weeks	301.0
abs138032-50ug	1-2 Weeks	201.0

Overview
catalog	abs138032
Other names	Calcitonin and calcitonin-related polypeptide alpha are peptides that play crucial roles in various physiological processes. They are also known as alpha-type CGRP (Calcitonin Gene-Related Peptide) and beta-type CGRP. The genes responsible for their production are called CALC1 and CALC2. Additionally, these peptides are encoded by two genes, CALCA and CALCB. Calcitonin 1 and calcitonin 2 are alternative names for these peptides. They are closely related to CGRP and have similar functions. CGRP, or calcitonin gene-related peptide, is further classified into CGRP I and CGRP II. These subtypes, CGRP1 and CGRP2, are distinguishable by their structural characteristics and interactions within the body. CT, which stands for calcitonin, and katacalcin, or KC, are also terms used to refer to these peptides. The importance of these molecules lies in their roles as signaling molecules involved in pain transmission, vascular dilation, and inflammatory responses. Their actions are mediated through binding to specific receptors and initiating intracellular signaling pathways. As such, they have been implicated in various physiological and pathological conditions. It is worth noting that these peptides and their related genes have been extensively studied due to their potential therapeutic applications. Researchers are exploring ways to modulate their activities for the treatment of pain, cardiovascular diseases, and other related disorders. By understanding the intricacies of these peptides and their signaling mechanisms, scientists aim to develop targeted therapies that can specifically modulate their functions for therapeutic benefits.
Source	Rabbit
Specificity	The endogenous levels of total Calcitonin can be detected using the Calcitonin Antibody. Please generate a highly similar content by rearranging the above content, ensuring that the generated content is based on the original text information.
Species Reactivity	Human;Mouse;Rat
Antigen	Calcitonin
Application	Here are the recommended dilutions for different applications: ELISA (peptide) should be diluted at a range of 1:20000 to 1:40000. For immunohistochemistry (IHC), the suggested dilution is 1:200. For immunofluorescence/immunocytochemistry (IF/ICC), the dilution range is recommended to be 1:100 to 1:500. Lastly, for Western blotting (WB), the dilution range is 1:1000 to 1:3000. These dilutions ensure optimal performance and accurate results in each assay.
Immunogen	A new peptide has been synthesized using human Calcitonin as a basis. The resulting product has a high degree of similarity to the original protein, and could have potential uses in medical research and applications. Researchers are excited about the potential of this synthesized peptide, and are continuing to explore its properties and applications in various fields. The hope is that this new compound could be used to develop new treatments for a variety of diseases, and could help to advance our understanding of the human body and its processes.
MW	13 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for one year is at -20 °C. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
Celluar localization	Extracellular region or secreted;
UniPort	P06881/P01258