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Rabbit Anti-CD276 Polyclonal Antibody#abs132694

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Description

Catalog-specification	Delivery time	USD price
abs132694-50ug	1-2 Weeks	201.0
abs132694-100ug	1-2 Weeks	301.0

Overview
catalog	abs132694
Description	T-cell-mediated immune response regulation may involve this protein. It could potentially protect tumor cells by inhibiting natural-killer cell lysis and serve as a marker for detecting neuroblastoma cells. Additionally, it may contribute to acute and chronic transplant rejection and regulate lymphocytic activity at mucosal surfaces. Moreover, it might play a crucial role in creating an appropriate immunological environment for the placenta and fetus during pregnancy. Both isoform 1 and isoform 2 seem to have similar capabilities in modifying CD4 T-cell responses. Interestingly, isoform 2 can enhance the activation of cytotoxic T-cells and specifically stimulate the production of interferon gamma when T-cell receptor signaling is present.
Other names	CD276, also known as 4Ig B7 H3 or B7 homolog 3, is a costimulatory molecule encoded by the AU016588 gene. It is also referred to as B7-H3 or B7RP-2. The CD276 antigen plays a crucial role in immune regulation and is involved in various biological processes. It is identified as a CD antigen and is present on the surface of cells. The CD276 molecule is flagged as a precursor and belongs to the PSEC0249 protein family. Additionally, it is listed as UNQ309/PRO352.
Source	Rabbit
Specificity	The CD276 antibody is designed to identify total CD276 levels endogenously present within a sample. This means that the antibody is capable of detecting all forms and isoforms of CD276 that are naturally present in the biological material being analyzed. Overall, the purpose of the antibody is to help researchers and clinicians better understand the expression and function of CD276 in various contexts. By providing a sensitive and specific way to measure CD276 levels, the antibody can support investigations into its potential role in diseases and therapeutic interventions.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Horse;Pig;
Antigen	CD276
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	57 kDa，110kd
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Tissue specificity	Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q5ZPR3