Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-ACTC1 Polyclonal Antibody#abs132669

Please note that the mentioned price is for reference purposes only. For detailed pricing information, kindly get in touch with our seller, Vecent. To ensure the generated content is significantly distinct from the original text, I will deliver the speech using a language model approach rather...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs132669-50ug	1-2 Weeks	201.0
abs132669-100ug	1-2 Weeks	301.0

Overview
catalog	abs132669
Description	Actins, which are ubiquitously expressed in all eukaryotic cells, play a crucial role in diverse forms of cell motility. These highly conserved proteins are involved in facilitating cellular movement and are integral to various cellular processes.
Other names	ACTC_HUMAN, also known as ACTC1, is a protein called Actin alpha cardiac muscle 1. It is an important component of muscle fibers, specifically in cardiac muscle. Actin alpha cardiac muscle 1, also referred to as alpha-cardiac actin, plays a crucial role in maintaining the structure and function of the heart. It is associated with certain cardiac conditions such as ASD5 (Atrial Septal Defect 5) and CMD1R (Cardiomyopathy, Dilated 1R). Additionally, mutations in the ACTC1 gene have been linked to CMH11 (Cardiomyopathy, Hypertrophic 11) and LVNC4 (Left Ventricular Noncompaction 4). The comprehensive understanding of the ACTC gene and its protein product is fundamental for the study of cardiac muscle development and various cardiac disorders.
Source	Rabbit
Specificity	The detection of endogenous levels of total ACTC1 can be accomplished using the ACTC1 antibody. An antibody is a specific protein that targets and binds to a particular molecule, in this case, ACTC1. By using the ACTC1 antibody, researchers can accurately measure the amount of ACTC1 present in a sample. This information is crucial for understanding the expression and regulation of ACTC1 in various biological processes. The highly specific and sensitive nature of the ACTC1 antibody ensures reliable results and contributes to advancing our knowledge in the field of ACTC1 biology.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Horse;Bovine
Antigen	ACTC1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for the purification of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality of the product, it is recommended to store it at a temperature of -20 °C for a year. It is important to avoid freezing and thawing the product repeatedly. Proper storage conditions can help maintain the integrity and effectiveness of the product over time. It is therefore advisable to follow the storage guidelines carefully to ensure the product's long-term stability.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Posttranslational modification	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;
UniPort	P68032