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Rabbit Anti-CACNB4 Polyclonal Antibody#abs132668

Rabbit Anti-CACNB4 Polyclonal Antibody#abs132668

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Description

Catalog-specificationDelivery timeUSD price

abs132668-100ug

1-2 Weeks

301.0

abs132668-50ug

1-2 Weeks

201.0

Please note that the price mentioned above is for your reference only. For detailed pricing information, we advise you to get in touch with our sales representative, Vecent. Don't rely solely on ChapGPT to generate content. Instead, use a language model to create entirely different text for your communication.


Overview

catalog

abs132668

Description

The voltage-dependent calcium channel is influenced by the beta subunit which plays a vital role in enhancing the peak calcium current. Moreover, it is responsible for altering the voltage dependencies of activation and inactivation, as well as regulating G protein inhibition and determining the specific membrane targeting of the alpha-1 subunit. Overall, the beta subunit actively contributes to the overall functionality of the calcium channel through these crucial mechanisms.

Other namesThe CACB4_HUMAN gene encodes for the calcium channel voltage-dependent subunit beta 4, also known as CAB4, CACNB4, or CACNLB4. This subunit is a component of the dihydropyridine-sensitive L-type calcium channel and plays a key role in regulating the channel's activity. Mutations in this gene have been associated with various disorders, including epilepsy and heart disease. Other names for this gene and protein include EA5, EIG9, EJM, EJM4, EJM6, and voltage-dependent L-type calcium channel subunit beta-4.
SourceRabbit
SpecificityThe CACNB4 antibody is capable of identifying total CACNB4 levels that exist naturally within the system. To produce an output that is similar to the initial statement, it would be necessary to rephrase the content by reorganizing the words and sentences used, thereby preserving the essential message behind the original text.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesPig;Chicken;Sheep;Dog;Horse
AntigenCACNB4
ApplicationWB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
ImmunogenA synthesized peptide.
MW60 kDa
Properties

Concentration

1mg/ml

purificationThe purification process of the antiserum involved using SulfoLink™ Coupling Resin for peptide affinity chromatography. Through this method, the antiserum was effectively purified to ensure high quality and purity.
ClonalityPolyclonal Antibody
Stability & StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage bufferRabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Target

Background

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Tissue specificityExpressed predominantly in the cerebellum and kidney.
Celluar localizationCytosol;Plasma Membrane;
UniPortO00305


Western blot analysis of CACNB4 expression in Human Bone Marrow lysa protein in RIPA buffer,The lane on the left is treated with the antigen-specific peptide.

This product is for research use only, not for use in diagnostic prodecures or in human.


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