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Rabbit Anti-TUSC4 Polyclonal Antibody#abs139589

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Description

Catalog-specification	Delivery time	USD price
abs139589-100ug	1-2 Weeks	301.0
abs139589-50ug	1-2 Weeks	201.0

Overview
catalog	abs139589
Other names	The 2810446G01Rik gene, also known as G21 protein or Gene 21 protein, shows homology to yeast nitrogen permease, which is considered a candidate tumor suppressor. It is also known as Nitrogen Permease Regulator 2-like protein or NPR2L. NPRL2_HUMAN, Tumor suppressor candidate 4, or TUSC4 protein, are other names used for this gene. NPR2 and NPR2-like protein are also alternate names of this gene. The function of this gene is yet to be fully understood, but studies suggest that it may play a role in regulating nitrogen metabolism. Further research is required to fully explore the potential of this gene in the context of human health and disease.
Source	Rabbit
Specificity	Endogenous levels of total TUSC4 can be detected using the TUSC4 Antibody. The TUSC4 Antibody is designed to specifically target and identify the native expression of TUSC4 protein within an organism. Its high sensitivity and specificity make it an ideal tool for studying the endogenous levels of total TUSC4. By accurately detecting and quantifying TUSC4 protein, researchers can gain valuable insights into its biological functions and potential roles in various cellular processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Zebrafish;Dog;Horse
Antigen	TUSC4
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TUSC4.
MW	44 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly pure product was obtained by this method.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles as this can have a negative impact on its stability and effectiveness. It is advisable to adhere to these storage instructions to ensure the product remains viable for its intended use over an extended period.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Tissue specificity	Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888). Expressed in most lung cancer cell lines tested.
Celluar localization	Lysosome;
UniPort	Q8WTW4