Rabbit Anti-MUC13 Polyclonal Antibody #abs130361

abs130361-50ug

1-2 Weeks

201

abs130361-100ug

1-2 Weeks

301

Description

MUC13 is a type of transmembrane mucin that is found in both epithelial and hemopoietic cells. It is believed to be involved in cell signaling, and is composed of beta subunits that form a homodimer. By rearranging the original text, this highly similar content conveys the same key information in a slightly different manner.

Other names

Colon cancer down-regulated 1 (DRCC1) is also known as FLJ20063 and is commonly referred to as MUC 13 or Mucin 13. This gene has been identified as being down-regulated in colon cancer, highlighting its potential significance in this disease. Mucas the primary protein encoded by MUC13, it is an associated mucin that is located on the cell surface. With the alternative name PRO20221, MUC13 is also referred to as RECC or UNQ6194.

Source

Rabbit

Specificity

MUC13 Antibody detects endogenous levels of MUC13.

Species Reactivity

Human;Mouse

Application

The recommended dilutions for using this antibody are as follows: for Western Blotting, use a dilution range of 1:500 to 1:2000; for Immunohistochemistry, use a dilution range of 1:50 to 1:200; for Immunofluorescence/Immunocytochemistry, use a dilution range of 1:100 to 1:500; and for ELISA (peptide), use a dilution range of 1:20000 to 1:40000. It is important to correctly dilute the antibody in order to achieve accurate and reproducible results in your experiments. Follow the manufacturer's instructions for antibody dilution and ensure proper handling and storage of the antibody to maintain its stability and efficacy.

Immunogen

A synthesized peptide derived from human MUC13.

Properties

Concentration

1mg/ml

Purification

SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. A highly purified anti-body was obtained after this process.

Clonality

Polyclonal Antibody

Stability & Storage

To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this can lead to a decrease in product quality. Therefore, it is highly advisable to store the product in a cool, dry location to maintain its efficacy over time.

Storage buffer

This solution contains Rabbit IgG in phosphate buffered saline, with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at -20°C. The solution remains stable for a period of 12 months from the date of receipt.

Target

Background

There is a transmembrane mucin that is found in both epithelial and hemopoietic cells, and it is believed to be involved in cellular signaling. This particular mucin may play an important role in communication between cells, and its presence in both types of cells suggests that it is involved in a wide range of physiological processes. The functions of this mucin are still being studied, but researchers have already identified several potential uses for it in the treatment of various diseases and disorders. Overall, this transmembrane mucin appears to be a key player in the complex network of signaling pathways that regulate cellular behavior.

Tissue specificity

The expression of this protein is predominant in epithelial tissues, especially those lining the respiratory and gastrointestinal tracts, including the trachea, large intestine, and stomach, among others. Additionally, it is highly expressed in the kidney, small intestine, and appendix.

Posttranslational modification

The cleavage occurs in a specific area, likely between the first EGF domain and the SEA domain, resulting in two subunits called alpha and beta. The beta subunit contains the cytoplasmic tail, while the alpha subunit carries the extracellular tail. Intrachain disulfide bonds play a crucial role in facilitating the formation of dimers through homooligomerization. Moreover, it is worth noting that this protein is highly N-glycosylated, indicating the presence of numerous attached sugar molecules. Let me know if you need any further information.

Celluar localization

Cytosol;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;

UniPort

Q9H3R2