TLR7 Polyclonal Antibody #abs115210

abs115210-50ul

In Stock

228

Other names

TLR7-like

Source

Rabbit

Species Reactivity

Human,Mouse,Rat

Application

IHC 1:50 - 1:200
IF 1:50 - 1:200

Immunogen

A fusion protein made through recombination has been developed, which contains a specific sequence that corresponds to amino acids 30-230 found in the human TLR7 protein (NP_057646.1). The aim of this protein is to create a highly similar content that remains true to the original text. This fusion protein has been devised with the intention of producing effective results rooted in the initial information.

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3 is a buffer solution. It is composed of sodium azide at a concentration of 0.02% and glycerol at a concentration of 50%. The pH of this buffer solution is 7.3.

Target

Background

The gene in question encodes a protein that belongs to the Toll-like receptor (TLR) family. TLRs are integral in recognizing and activating innate immunity in response to pathogens. These receptors are structurally and functionally similar across different species, from Drosophila to humans. By recognizing pathogen-associated molecular patterns (PAMPs), TLRs trigger the production of cytokines that are necessary for effective immune responses. The expression of TLRs varies across different tissues and organs. This particular gene is predominantly expressed in the lungs, placenta, and spleen, and is located in close proximity to another TLR family member called TLR8 on the X chromosome.

Celluar localization

The endoplasmic reticulum membrane is a vital component of the cell that plays a key role in protein synthesis and lipid metabolism. It is responsible for the formation of cytoplasmic vesicles that help transport proteins and other molecules throughout the cell. The endosome is another important structure that functions as a transportation hub for molecular cargo. It receives materials from the plasma membrane and sorts them for delivery to various cellular destinations, including the lysosome.
The lysosome is a specialized organelle that contains digestive enzymes used to break down and recycle cellular waste. It is essential for maintaining proper cellular function and preventing the buildup of toxic materials. On the other hand, the single-pass type I membrane protein plays a crucial role in cell signaling and communication. These proteins are embedded in the cell membrane and act as receptors for various hormonal and chemical signals.
Lastly, the phagosome is a membrane-bound vesicle that forms around foreign substances engulfed by the cell. It is the first step in the process of phagocytosis, whereby certain immune cells engulf and destroy invading pathogens. Overall, these structures and proteins are critical for the proper functioning of the cell and its ability to maintain homeostasis.

UniPort

Q9NYK1