Rabbit Anti-ES8L2 Polyclonal Antibody #abs130359

abs130359-50ug

1-2 Weeks

201

abs130359-100ug

1-2 Weeks

301

Description

EPS8L2, a member of the EPS8 protein family, is known to stimulate the guanine exchange activity of SOS1, thereby contributing to the activation of SOS1. Its involvement in membrane ruffling and actin cytoskeleton remodeling suggests its crucial role in cell motility and shape changes. EPS8L2 interacts with ABI1, forming a complex that also includes SOS1. Furthermore, EPS8L2 associates with F-actin, which further supports its involvement in actin cytoskeleton dynamics. Additionally, alternative splicing of the human EPS8L2 gene gives rise to two isoforms of the protein.

Other names

Epidermal growth factor receptor kinase substrate 8 like protein 2, also referred to as EPS8L2, EPS8R2, or FLJ16738, plays a significant role in the epidermal growth factor (EGF) signaling pathway. This protein is closely related to EPS8-like protein 2 and EPS8-related protein 2.
EPS8L2 is a member of the EPS8 family of proteins that act as scaffolds for the assembly of proteins involved in signal transduction pathways. EPS8L2 has been found to be involved in regulating cell proliferation, migration, and invasion, which are critical processes in cancer development and metastasis.
Studies have shown that EPS8L2 is highly expressed in a variety of cancer cell lines, including breast, lung, and pancreatic cancers. Additionally, it has been reported that EPS8L2 may act as a prognostic marker for cancer, as its expression has been correlated with poor overall survival rates in patients with certain types of cancer.
Research is ongoing to further elucidate the role of EPS8L2 in the development and progression of cancer. By better understanding the function of this protein, it may be possible to develop novel therapeutics for the treatment of cancer.

Source

Rabbit

Specificity

ES8L2 Antibody detects endogenous levels of ES8L2

Species Reactivity

Human;Mouse

Application

WB can be performed at dilutions ranging from 1:500 to 1:2000, while IF/ICC can be done at dilutions of 1:100 to 1:500. For ELISA using peptides, the recommended dilution range is 1:20000 to 1:40000. These dilutions are based on the original information provided and can be used as a reference for experimental protocols.

Immunogen

A synthesized peptide derived from human ES8L2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

In order to preserve the quality, it is recommended to store the product at a temperature of -20 °C for a period of one year. It is crucial to avoid subjecting it to repeated freeze/thaw cycles.

Storage buffer

The storage conditions for Rabbit IgG are as follows: It should be stored at -20°C in phosphate buffered saline with a pH of 7.4. The solution should also contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the product is guaranteed for 12 months from the date of receipt.

Target

Background

This protein enhances the guanine exchange activity of SOS1, which is involved in membrane ruffling and reorganization of the actin cytoskeleton.

Tissue specificity

Detected in fibroblasts and placenta.

Celluar localization

The content above describes three different locations within a cell: the cytosol, extracellular region or secreted, and plasma membrane. In order to generate a highly similar content while rearranging the text, we might say:
The cytosol is a location within a cell where the environment is carefully regulated. Outside of the cell, in the extracellular region or secreted environment, different factors come into play. The plasma membrane separates these two environments, acting as a barrier and control point for what enters and exits the cell.

UniPort

Q9H6S3